What is the potential of measuring the enantiomeric ratio of drugs using supercritical fluid chromatography–MS?

“Supercritical fluid chromatography allows fast and efficient separation of enantiomers.” Analytical chemists are always looking for more efficient techniques to meet analytical challenges of today's regulatory and scientific requirements. One technique that has made drastic improvements in recent years is supercritical fluid chromatography (SFC).   Since its early days, this separation technique has emerged as a powerful tool for both analytical and preparative scientists. In 2012, new instruments for analytical purpose were introduced that offer reliability, robustness and sensitivity never before possible. Since then, the interest in this technique was renewed. Indicated by the number of peer-reviewed articles, analytical SFC...