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The articles database is a growing compilation of wide-ranging articles from bioanalysis – including primary research, reviews, White Papers, event reports, interviews and more – drawn from a range of sources.
Week by week the database grows, and if you sign up for our weekly eNewsletter (which can be done in 'MyZone'), you will receive regular updates on the new content frequently being added to the Zone.
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Interview with Leroy Hood (Institute of Systems Biology)Leroy Hood received an MD from Johns Hopkins and a PhD from Caltech. He was a professor at Caltech for 22 years, at the University of Washington for 8 years and has been President and co-founder of...Posted 16/05/2013 (2 days ago)- Interview with Steve Lowes (Quintiles)Steve Lowes is Vice President of Scientific for Quintiles’ Bioanalytical & ADME Labs. He has focused on quantitative bioanalysis since his postgraduate work at the Open University...Posted 09/05/2013 (1 week ago)
Foreword to J Burrows articles“Altering the status quo always takes someone putting something out into the community and requires others who are willing to give it a try. This is my hope and my challenge to our...Posted 09/05/2013 (1 week ago)
Determination of urinary 6-mercaptopurine and three of its metabolites by HPLC–UV coupled with the iodine–azide reactionBackground: The presented method is able to determine 6-mercaptopurine (6-MP), 6-thioguanine, 6-mercaptopurine riboside and 6-thioguanine riboside in urine, and is thereby dedicated to control of...Posted 09/05/2013 (1 week ago)
Hair as an alternative matrix in bioanalysisAlternative matrices are steadily gaining recognition as biological samples for toxicological analyses. Hair presents many advantages over traditional matrices, such as urine and blood, since it...Posted 09/05/2013 (1 week ago)- How the accelerator MS community are trying to fit into the regulatory framework: are the BMV guidances relevant?“…it is to be hoped that as a result of the efforts of the European Bioanalysis Forum and initiatives such as the Global Bioanalysis Consortium, future revisions of the Bioanalytical...Posted 02/05/2013 (2 weeks ago)
- Molecularly imprinted SPE combined with dispersive liquid–liquid microextraction for selective analysis of telmisartan in biological and formulation samplesBackground: The present communication describes the combination of molecularly imprinted SPE and dispersive liquid–liquid microextraction for the selective preconcentration and determination of...Posted 18/04/2013 (1 month ago)
- Quantification of the sixth DNA base 5-hydroxymethylcytosine in colorectal cancer tissue and C-26 cell lineBackground: DNA methylation at the five position of cytosine is well recognized as an important epigenetic modification in human health and disease. Recent evidences demonstrated that...Posted 18/04/2013 (1 month ago)
- Is the tiered immunogenicity testing of biologics the adequate approach in preclinical development?“…immunogenicity testing remains a case-by-case study, in which preclinical assessment can deliver pivotal dataabout the immunogenic potential of a biologic.”
Posted 16/04/2013 (1 month ago)
Webinar: Addressing the Needs of Bio-analysis with New SPE Technologies – SOLAPosted 05/04/2013 (1 month ago)
- Investigating Matrix Interference in Analysis of Antiarrhythmic Cardiac Drugs in PlasmaPosted 28/03/2013 (2 months ago)
- Interview with Ron Bowsher (AIT BioSciences, B2S Consulting, & B2S Labs)In March 2013, Ronald Bowsher (AIT BioSciences) talks to Alexandra Sklan at Bioanalysis about his current bioanalytical career, his involvement in the American Association of Pharmaceutical...Posted 28/03/2013 (2 months ago)
- Hollow-fiber liquid-phase microextraction and chiral LC–MS/MS analysis of venlafaxine and its metabolites in plasmaBackground: An enantioselective analytical method was developed and validated for determination of venlafaxine and its metabolites O-desmethylvenlafaxine and N desmethylvenlafaxine in plasma samples....Posted 21/03/2013 (2 months ago)
Dispersive liquid–liquid microextraction of propranolol enantiomers from human plasma based on the solidification of a floating organic dropletBackground: A dispersive liquid–liquid microextraction based on the solidification of a floating organic droplet was developed and validated for the extraction of propranolol enantiomers from...Posted 21/03/2013 (2 months ago)
The European Bioanalysis Forum community’s evaluation, interpretation and implementation of the European Medicines Agency guideline on Bioanalytical Method ValidationThe European Medicines Agency’s (EMA) 2011 guideline on bioanalytical method validation (BMV) was evaluated and subsequently intensely discussed by the European Bioanalysis Forum (EBF) during a...Posted 19/03/2013 (2 months ago)- Society Spotlight: China Bioanalysis ForumThe China Bioanalysis Forum (CBF), a volunteer and science focused group, was recently formed. The formation of CBF is a response to the urgent needs of updating current Chinese bioanalytical...Posted 19/03/2013 (2 months ago)
- Quantitative surface-assisted laser desorption/ionization–MS approaches for bioanalysis “…SALDI-MS using functionalized nanoparticles holds great potential of becoming a primary technique for protein analysis and for MS imaging. ”
Posted 19/03/2013 (2 months ago)
- Top ten: Critical topics in ensuring data quality in bioanalytical LC–MS method developmentPosted 15/03/2013 (2 months ago)
- Comparison of newly developed immuno-MS method with existing DELFIA® immunoassay for human chorionic gonadotropin determination in doping analysisBackground: The performance of a method for MS determination of human chorionic gonadotropin (hCG) was compared with a reference method currently used in World Anti-Doping Agency accredited doping...Posted 07/03/2013 (2 months ago)
- Analytical platform for glycomic characterization of recombinant erythropoietin biotherapeutics and biosimilars by MSBackground: Erythropoietin is a therapeutic glycoprotein that stimulates red blood cell production. The quality, safety and potency of recombinant erythropoietins are determined largely by their...Posted 07/03/2013 (2 months ago)
Conference Report: Bioanalysis-related topics presented at the International Conference and Exhibition on Biowaivers and BiosimilarsThis conference of approximately 30 professionals attracted a diverse group of attendees, whose expertise spanned the broad topics of development, production, testing and regulation of biosimilars....Posted 28/02/2013 (3 months ago)- European perspective on biosimilars “Although dogged by much controversy, the scientific approach adopted in the EU for approval of biosimilars to ensure patient safety has been sound.”
Posted 28/02/2013 (3 months ago)
- Analytical and bioanalytical assay challenges to support comparability studies for biosimilar drug development"..to ensure safety and efficacy of a biosimilar in comparison with its originator drug, preclinical and clinical comparabiltiy studies must be conducted according to the regulatory guidance for...Posted 28/02/2013 (3 months ago)
- Mini Focus: bioanalysis of biosimilarsPosted 28/02/2013 (3 months ago)
- Dispersive liquid–liquid microextraction based on solidification of floating organic droplet followed by spectrofluorimetry for determination of carvedilol in human plasmaBackground: Simple, chip and rapid analytical methods are required in biomedical analysis laboratories to support therapeutic drug monitoring units in hospitals. The present work aimed to provide...Posted 28/02/2013 (3 months ago)
- Ultrasensitive and automated 1 pg/ml fluticasone propionate assay in human plasma using LC–MS/MSBackground: To develop and validate an ultrasensitive bioanalytical assay for quantitation of fluticasone propionate in human plasma, aliquots of 0.6 ml of K3EDTA human plasma were treated with zinc...Posted 28/02/2013 (3 months ago)
- Strategic regulatory approaches for the qualification of a biomarker assay for safety useBiomarkers can be defined as key molecular or cellular events that link a specific biological event to a health outcome. As such, biomarkers play an important role in understanding the relationships...Posted 26/02/2013 (3 months ago)
- Host Cell Protein Workshop at the 2012 Annual Bioassay Meeting of the Biopharmaceutical Emerging Best Practices Association2012 Annual Bioassay Meeting of the Biopharmaceutical Emerging Best Practices Association
Lisbon, Portugal, 26–28 September 2012
Posted 26/02/2013 (3 months ago)
- A hitchhiker’s guide to outsourcing ADME studies: the inside of outsourcingAmerican Association of Pharmaceutical Scientists 2012 Annual Meeting and Exposition.
Chicago, IL, USA, 17 October 2012
Posted 26/02/2013 (3 months ago)
- 3D thinking: computational aids for the bioanalyst“The word ‘quantum’ immediately brings images of such scientific giants as Heisenberg and Schrodinger to mind. Yet we do not need to be a physicist to apply quantum mechanics on a...Posted 26/02/2013 (3 months ago)
