Bioanalysis Zone

Disposable pipette extraction for the simultaneous determination of biperiden and three antipsychotic drugs in human urine by GC–nitrogen phosphorus detection

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Disposable pipette extraction with reversed-phase sorbent is proposed for the fast and simple GC determination of the antipsychotic drugs chlorpromazine, olanzapine, clozapine and biperiden – an anticholinergic drug – in human urine. The method was validated and successfully applied to postmortem urine samples. The analytical run was 11 min and lidocaine was used as the internal standard. Results: The developed method showed good linearity, over the range of 0.34 to 5 ng/µl, for all compounds.

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