Watch a presentation by Xiwei (Emmi) Zheng, winner of the 2015 YIA. In this presentation Emmi presents the research, which led to her being selected as winner of the YIA.
Emmi’s research involves studying the reversible interaction of drugs and hormones with serum proteins using high-performance affinity chromatography (HPAC). The rate constants and binding constants of these systems are of interest, as they can help us determine the biologically active form of drugs and improve our understanding of the interactions of therapeutics with their targets.
Emmi details the novel HPAC method she created to simultaneously determine both the equilibrium constants and rate constants for this type of interaction. The HPAC method in a multi-dimensional system allowed for the measurement of the free fraction of drugs in samples such as human serum. A key benefit of the technique is that it is label-free, requires a short analysis time and only requires microliter volumes of sample.
Xiwei (Emmi) Zheng received her BS degree in Chemistry from Jilin University (China) in 2010, and her PhD degree in analytical chemistry from Dr David Hage’s research group at the University of Nebraska-Lincoln (NE, USA; UNL) in 2015. She is currently a postdoctoral fellow in the Hage group at UNL. Her research has mainly focused on the study of drug-or hormone-protein interactions by using the technique of high-performance affinity chromatography (HPAC). She has developed novel methods based on HPAC to rapidly and efficiently measure the equilibrium constants and rate constants for drug-protein interactions.
By using HPAC as part of a multi-dimensional system, she has also been able to measure the free fractions of drugs and hormones in complex samples such as serum or those that contain several forms of a drug or more than one binding protein.
Xiwei has published 19 scientific papers and reviews, eight of which have her as the first author. She has won several awards for her work, including the best poster award at the 2012 FACSS meeting, the 2015 Alumni Graduate Research Assistant Award from the UNL Chemistry Department, and the 2015 Bioanalysis Young Investigator Award.
Kelly is a Senior Manager for DMPK within Waters Worldwide Marketing for the Pharmaceuticals Business. She joined Waters in 2014 following seven years working in product management, product marketing and new product development with ALPCO, a provider of immunoassays to the clinical and life sciences research sectors. Prior to joining ALPCO, Kelly completed a postdoctoral fellowship at Boston Children’s Hospital within the Division of Endocrinology and obtained her PhD in Molecular Biology & Nutrition from the University of Connecticut.
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