Bioanalysis Zone

Bioanalysis of antibody drug conjugates using hybrid LBA/LC-MS and the BioBA Solution

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Antibody drug conjugates (ADCs) represent a challenge for bioanalytical scientists, due to their inherent heterogeneity (i.e., different Drug-to-Antibody Ratios), high molecular weight,  presence in complex biological matrices and changes in ADC composition in biological samples. In addition to traditional immunoassay based methods, LC-MS is a powerful and efficient technology for ADC bioanalytical quantitation. This webinar will examine different methodologies for the bioanalysis of ADCs, and will highlight a hybrid LBA/LC-MS/MS assay using the SCIEX BioBA Sample Preparation Kit that enables a selective, immunocapture-based workflow with magnetic beads. This kit-based strategy allows users to develop sensitive and reliable bioanalytical assays with a wide linear dynamic range, with a simple step-wise protocol.

What will you learn?

  • Different assay techniques for ADC bioanalysis by LC-MS
  • Development of a LBA/LC-MS/MS assay for the quantitation of ADCs
  • How the SCIEX BioBA Solution provides an easy-to-use workflow for biologics quantitation

Who may this interest?

  • Bioanalytical scientists transitioning from small molecule to large molecule bioanalysis
  • Biopharma/CROs performing biologics and ADC bioanalysis

Speaker

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Rafiq Islam
Senior Director, Bioanalytical Services,
Celerion

Rafiq Islam is the Senior Director of Bioanalytical Services at Celerion Inc. (NE, USA). In his current role, he is responsible for the scientific and operational leadership of both small- and large-molecule bioanalysis, which includes the development and validation of bioanalytical methods and execution of sample analysis to support pharmacokinetic, immunogenicity, bioequivalence and biosimilar studies. Previously, he served as the Scientific Director for Biopharma Services at EMD Millipore (MO, USA). He held similar positions as the head of a bioanalytical department at Covance Inc. (AZ, USA) and Huntingdon Life Sciences (NJ, USA). He also held several positions of increasing responsibility with Curagen Corporation. He has over 18 years of biotechnology industry experience.

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