Bioanalysis Zone

Expert Series: Species differences in the hepatobiliary disposition and regulation of bile acids



Kyunghee Yang

Kyunghee Yang, Ph.D., is a scientist for DILIsym Services, Inc. and software developer working on the DILI-sim Initiative modeling team. Dr. Yang’s research focuses on the computational modeling of drug-induced liver injury (DILI) regarding interference of bile acid transport by hepatotoxic drugs

Dr. Yang received her B.S. in pharmacy and M.S. in pharmacokinetics from Seoul National University, South Korea, and Ph.D. in Pharmaceutical Sciences from University of North Carolina at Chapel Hill. Her graduate research focused on defining the mechanisms of DILI involving the interactions in efflux of bile acids and drugs. As a result of her research, she earned numerous fellowship awards.

Dr. Yang has published scientific papers in the areas of drug metabolism and transport, regulation of drug metabolizing enzymes during pregnancy, and systems pharmacology modeling of DILI. She has been invited to speak at multiple scientific meetings including 3

Kenneth Brouwer

Dr. Brouwer is Associate Dean for Research and Graduate Education, UNC Eshelman School of Pharmacy, and Kenan Distinguished Professor in the School of Pharmacy and Curriculum in Toxicology at UNC-Chapel Hill. Dr. Brouwer was Founding Director of the UNC Pharmacokinetics/Pharmacodynamics Fellowship Program and she directs an NIH-funded research program focused on hepatobiliary drug disposition, hepatic transport proteins, and development/refinement of in vitro models to predict in vivo hepatic drug disposition, drug interactions, and hepatotoxicity.

In this webinar Kyunghee Yang and Kenneth Brouwer explain how the disposition of bile acids in various species is governed by their physicochemical properties and carrier-mediated transport. The synthesis, metabolism, and transport of bile acids varies across species. Interpretation and extrapolation of transporter data can be complicated by species differences, leading to poor prediction of clinical effects from preclinical data. The species differences in bile acid synthesis, metabolism, transport and regulation will be discussed.

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