Bioanalysis Zone

Improving LC–MS throughput and capacity for rapid ADME screening: A case study

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Absorption, distribution, metabolism and elimination (ADME) properties of drug candidates are vital in the profiling of drug candidates for lead optimization in the early stages of drug development. As the number of novel molecular entities increase for early profiling, challenges in throughput arise for laboratories performing screening analyses for these potential drug candidates by LC–MS/MS. Time and capacity go hand in hand in sample acquisition and can greatly affect the turnaround time of data delivery to clients for decisions on lead candidates.

This webinar will focus on the implementation of a high-throughput UHPLC–MS/MS assay using an ExionLC™ and SCIEX Triple Quad system. Learn how gaining throughput and capacity on your current mass spectrometer by implementing a UPLC methodology can eliminate the need to purchase additional instrumentation, without the sacrificing ruggedness and robustness.

What will you learn?

  • Limitations of previous technologies for ADME workflows
  • How the ExionLC AD UHPLC System can improve throughput
  • Case study: Validation of Caco-2 cell line model using 22 model compounds per FDA guidance

Speaker

Shantanu Roychowdhury
Scientific Supervisor and Group Leader: ADME-Tox
Eurofins Panlabs, Inc.

Shantanu Roychowdhury has over 13 years of experience in biological sciences spanning from academia to industry.  Shantanu holds BSc degrees in biochemistry and mathematics from the University of Illinois at Urbana-Champaign (IL, USA). Shantanu has expertise in both large and small molecule mass spectrometry. Shantanu is currently the Scientific Supervisor and Laboratory Lead for ADME-Tox services at Eurofins Panlabs in Saint Charles (MO, USA).

For a full list of other webinars available on Bioanalysis Zone please see here.

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