Bioanalysis volume 9, issue 20

Issue 20 of Bioanalysis volume 9 is now available, including an editorial surrounding the factors which may impact PK measurements of antibody therapeutics alongside the latest methodologies, research articles and discussions of current bioanalytical challenges.

Explore the latest issue below, or head to the Bioanalysis webpage to find out more.

Editorial
Factors that impact pharmacokinetic measurements of antibody therapeutics: what is your PK assay telling you?

Methodology
Immunoprecipitation middle-up LC–MS for in vivo drug-to-antibody ratio determination for antibody–drug conjugates
LC–MS determination of fentanyl in human serum and application to a fentanyl transdermal delivery pharmacokinetic study
Multiplexing determination of cancer-associated biomarkers by surface-enhanced Raman scattering using ordered gold nanohoneycomb arrays

Research Article
Immunoaffinity LC–MS/MS for quantitative determination of a free and total protein target as a target engagement biomarker

Bioanalytical Challenge
Overcoming challenges associated with the bioanalysis of an ester prodrug and its active acid metabolite
Generation of assay positive controls for detection of isotype anti-drug antibodies for immunogenicity monitoring