Challenged to remove matrix interferences while dealing with the evolving complexity of biotherapeutics? In this webinar we will detail how to overcome background interference challenges, which might otherwise limit assay capabilities, through exploring and examining multiple case studies. We will illustrate how SelexION+® Differential Mobility Separation (DMS) technology offers a unique approach to separate isoforms and isobaric interferences and achieve improved levels of quantitation.
You will learn how to:
- Remove endogenous/exogenous isobaric interference (e.g., isomers)
- Reduce chemical/background noise to improve S/N ratio and promote achievable LLOQs
- Simplify exhaustive sample preparation and complex chromatographic separations
- Minimize time required for method development
- Key advantages of SelexION+® technology
Who may this interest?
- CROs, pharma and biotech organizations focused on enhancing selectivity for LC–MS quantitative bioanalysis
- Mass spectrometrists and bioanalytical scientists engaged in assay development
- Academics and students interested in the applications of ion mobility spectrometry
Dr. Mingluan Chen joined Altasciences (Laval, Canada) as Senior Scientist, Method Development after completing his PhD in micro-scale LC-MS for small molecules at Wuhan University (Hubei, China) in 2013. Over the past four years, Dr. Chen has been focusing on Innovator molecules as part of both preclinical and clinical drug development programs and has developed over 50 de novo LC-MS assays. He has also authored 20 peer-reviewed articles and has contributed to many scientific posters and presentations. Dr. Chen is currently focusing on the implementation of new technologies in bioanalysis alongside Altasciences’ Innovator team.