Bioanalysis Zone

Definitive profiling of plasma bile acids as potential biomarkers for human liver diseases using UPLC–HRMS

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Aim: Investigation of bile acids (BAs) as biomarkers for liver and kidney diseases has gained momentum recently to fulfill the needs in drug development and clinical practice, but a thorough and rapid profiling of BAs in human plasma has been hindered by the large interindividual variability and lack of selective methods.

Results: A selective and efficient UPLC-high resolution mass spectrometry method was developed and

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