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Ensuring biological sample integrity from collection to analysis for LC–MS workflows: case studies illustrating challenges in clinical trials


In this special report, Melanie Anderson (Merck and Co., Inc.; PA, USA) presents several case studies and discusses the logistical challenges associated with unstable compounds and unique matrices for LC–MS/MS workflows. She also discusses how we can ensure sample integrity and how this is crucial for providing reliable data from clinical trials. This article is from the special focus issue published by Bioanalysis on Stability Issues in Bioanalysis.

Keywords: analyte stabilitydried blood spot, peripheral blood mononuclear cellssample collectionsample integrity

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