Browsing: Biomarkers

A biomarker is a protein or small molecule that is indicative of homeostasis or a disease state. The concentration of a specific biomarker can indicate disease progression or a response to a therapeutic intervention.

Biomarkers are particularly important in the pharmaceutical industry to evaluate the safety and effectiveness of a drug and could also benefit the cost reduction of drug development by enabling early proof-of-concept studies for novel therapeutic targets, thus reducing costly drug attrition rates. The study of diagnostic and predictive biomarkers is also an area of great interest, with increasing focus on point-of-care biosensor systems.

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Scientists at the Johns Hopkins Kimmel Cancer Center (MD, USA) have completed a proof-of-principle study with results indicating the potential for a urine test for prostate cancer. The study identified cancer-specific changes in urinary RNAs and metabolites.

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