In this article from Bioanalysis, the authors review technical aspects and applications of image cytometers, the recent progress in the field and available commercial devices.
Browsing: Journal Articles
In this methodology from Bioanalysis, the authors investigate the detection of Ki67 – a prognostic and/or predictive biomarker in patients with malignancies – in human blood using flow cytometry for single-cell multiparameter analysis.
2018 White Paper on Recent Issues in Bioanalysis: focus on immunogenicity assays by hybrid LBA/LCMS and regulatory feedback (Part 2 – PK, PD & ADA assays by hybrid LBA/LCMS & regulatory agencies’ inputs on bioanalysis, biomarkers and immunogenicity)
This part of the 2018 White Paper published in Bioanalysis focuses on the recommendations for PK, PD and ADA assays by hybrid LBA/LCMS and regulatory agencies’ input.
2018 White Paper on Recent Issues in Bioanalysis: ‘A global bioanalytical community perspective on last decade of incurred samples reanalysis (ISR)’ (Part 1 – small molecule regulated bioanalysis, small molecule biomarkers, peptides & oligonucleotide bioanalysis)
This part of the 2018 White Paper published in Bioanalysis discusses the recommendations for LC–MS for small molecules, peptides, oligonucleotides and small molecule biomarkers.
This article from Bioanalysis is focused on the challenges in the development of flow cytometry bioanalytical methods to quantitatively measure CAR-T cell levels in adoptive cell therapy.
Challenges and opportunities in bioanalytical support for gene therapy medicinal product development
This review article from Bioanalysis> summarizes recent practices and considerations in bioanalytical support of pharmacokinetics and pharmacodynamics evaluations in gene therapy development with insight into method design, development and validations.
2018 White Paper on Recent Issues in Bioanalysis: focus on flow cytometry, gene therapy, cut points and key clarifications on BAV (Part 3 – LBA/cell-based assays: immunogenicity, biomarkers and PK assays)
This part of the 2018 White Paper published in Bioanalysis covers the recommendations for large molecule bioanalysis, biomarkers and immunogenicity using LBA and cell-based assays.
Bioanalysis> commissioning Editor, Rhiannon Finnie, reflects on the journal’s highlights from 2018 including special focus issues and the most popular articles of the year.
This review article from Bioanalysis> introduces the differences between UHPLC and HPLC, and reviews the use of UHPLC in the last 5 years when studying the glycosylation of proteins and glycoprofiling biopharmaceuticals.
Quantification of phenolic acid metabolites in humans by LC–MS: a structural and targeted metabolomics approach
In this research article from Bioanalysis, the authors quantified and identifed over 50 analytes from human biological matrices by HPLC, NMR and LC–MS to obtain structural information on phenolic acid metabolites.