The demand for analyzing biomarkers in drug development has increased dramatically with the advancement of precision medicine. In this editorial Weiping Shao (Frontage) discusses the challenges and key advice for outsourcing biomarker research.
Browsing: biomarker validation
In this interview Joel Mathews (Ionis Pharmaceuticals Inc., CA, USA) discusses his role in the development of biomarker, PK and immunogenicity assays in the development of protein therapeutics. He explains his interest in the field and explores the use of LBA for biomarker validation
In this Spotlight interview, Franklin Spriggs (KCAS; KS, USA) explains his interest in biomarkers and introduces the technologies and techniques utilized and offered by KCAS.
Learn how your lab can increase efficiencies while reducing costs in this overview of our MetaboQuan-R Method Packages and the details behind their development.
In this interview we talk to Timothy Olah (Bristol-Myers Squibb) about his research and role as Group Director. He discusses his group’s responsibility for developing quantitative methods to measure novel therapeutics and biomarkers in discovery.
KCAS has invested time and resources to qualify a number of multi-parameter immunophenotyping panels which can be utilized “off the shelf” or customized to meet our client’s particular needs.
MetaboQuan-r for bile acids in human serum: a rapid, targeted UPLC-MS/MS method for metabolomic research studies
Bile acids are an important class of biological molecules that are generated in the liver and play a central role in various biological functions, including cholesterol homeostasis. Quantitative analysis for research of bile acids using LC-MS is complicated by the presence of many isomeric compounds.Historically, this has meant that throughput has been compromised in order to separate these isomeric compounds. Here we demonstrate how these compounds can be separated, without compromising throughput, using Waters® CORTECS UPLC Technology combined with negative mode electrospray ionization mass spectrometry. This application note is also part of a MetaboQuan-R method package.
Expand your lab’s capabilities and rapidly increase coverage of a variety of in-demand metabolomics and lipid assays, while significantly reducing development times and the operating costs of running a wide range of assays. The Waters Targeted Omics Library, including the MetaboQuan-R and LipidQuan-R Rapid Targeted Omics Method packages, is an on-line database of method files and application notes for a variety of in-demand metabolite and lipid panels.
Find out more about the evolution of fit-for-purpose biomarker validations from an LBA perspective in this free article from Bioanalysis.