Browsing: biomarker validation

Biomarker discovery DNA biomarker
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The demand for analyzing biomarkers in drug development has increased dramatically with the advancement of precision medicine. In this editorial Weiping Shao (Frontage) discusses the challenges and key advice for outsourcing biomarker research.

LBA biomarker-validation-lba
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In this interview Joel Mathews (Ionis Pharmaceuticals Inc., CA, USA) discusses his role in the development of biomarker, PK and immunogenicity assays in the development of protein therapeutics. He explains his interest in the field and explores the use of LBA for biomarker validation

spotlight Waters image for bz
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Bile acids are an important class of biological molecules that are generated in the liver and play a central role in various biological functions, including cholesterol homeostasis. Quantitative analysis for research of bile acids using LC-MS is complicated by the presence of many isomeric compounds.Historically, this has meant that throughput has been compromised in order to separate these isomeric compounds. Here we demonstrate how these compounds can be separated, without compromising throughput, using Waters® CORTECS UPLC Technology combined with negative mode electrospray ionization mass spectrometry. This application note is also part of a MetaboQuan-R method package.

Spotlight Resources Waters image product listing
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Expand your lab’s capabilities and rapidly increase coverage of a variety of in-demand metabolomics and lipid assays, while significantly reducing development times and the operating costs of running a wide range of assays. The Waters Targeted Omics Library, including the MetaboQuan-R and LipidQuan-R Rapid Targeted Omics Method packages, is an on-line database of method files and application notes for a variety of in-demand metabolite and lipid panels.