Find out more about the validation of biomarkers in this interview with Hanna Ritzén, Managing Director Research and Development at Mercodia AB (Uppsala, Sweden).
To kick-start this special focus, we wanted to hear your thoughts on the topic – complete our short survey on the validation of biomarkers and be the first to receive our informative infographic collated from the survey results.
MetaboQuan-r for bile acids in human serum: a rapid, targeted UPLC-MS/MS method for metabolomic research studies
Bile acids are an important class of biological molecules that are generated in the liver and play a central role in various biological functions, including cholesterol homeostasis. Quantitative analysis for research of bile acids using LC-MS is complicated by the presence of many isomeric compounds.Historically, this has meant that throughput has been compromised in order to separate these isomeric compounds. Here we demonstrate how these compounds can be separated, without compromising throughput, using Waters® CORTECS UPLC Technology combined with negative mode electrospray ionization mass spectrometry. This application note is also part of a MetaboQuan-R method package.
In this Spotlight, we will be revisiting some of the key issues raised in a previous Spotlight: Biomarkers (and biosensors), as well as investigating advancements in the field and the development of techniques. We will hear from experts in the field about the key challenges they face, how they overcome them and how their research is helping to advance the development of human healthcare.
Single molecule counting (SMC™) technology enables precise measurement of molecules at levels previously undetectable, down to the femtogram/mL levels, allowing researchers to identify new biomarkers or assist in therapeutic development with an improved view of efficacy, safety and time course studies. Find out more in this video webinar from Millipore Sigma (MA, USA).
“Insulin assays have been used for decades, and although they were validated once upon a time, industry guidelines have since been updated, improved and changed. How do these old methods stand against modern needs and requirements?
In these two parts, Hanna Ritzén, Managing Director of Research and Development at Mercodia (Uppsala, Sweden), gives an introduction to life cycle management and how it can be implemented to improve and keep consistent measurement quality.
Developing bioanalytical LC–MS/MS methods for biotherapeutics and biomarkers: an interview with William Mylott
In this expert interview, William Mylott discusses developing bioanalytical LC–MS/MS methods for biotherapeutics and biomarkers.
Read time: 1 min
Researchers from La Jolla Institute for Allergy and Immunology (CA, USA) have identified a subset of T cells whose frequency could serve as an early childhood signature to predict the risk of developing asthma.
An author’s perspective: Ragu Ramanathan on an LC–MS/HRMS assay for quantifying coproporphyrins as organic anion-transporting polypeptide biomarkers
We talk to Ragu Ramanathan about his work on LC–MS/HRMS assay for quantifying coproporphyrins as organic anion-transporting peptide biomarkers