Webinar available to view on demand. Methods for the detection of drug-induced antibodies have become much more sensitive, but the question remains to be answered: are antibodies at this low concentration level clinically relevant?
As part of our Spotlight on the validation of biomarkers, we conducted a survey and compared the results to previous data. Find out more about the key trends, challenges and future potential for biomarker R&D in this informative infographic.
In this Spotlight interview, Franklin Spriggs (KCAS; KS, USA) explains his interest in biomarkers and introduces the technologies and techniques utilized and offered by KCAS.
Webinar available to view on demand. In this panel discussion, we hear from key experts in the field about their research and expertise, how they overcome key challenges associated with the technologies they work with and what they envision for the future of biomarker research and validation.
Current methods for the treatment of cancer include radiation, chemotherapy and surgical intervention, but alternative treatment modalities exist should these traditional methods prove unsuccessful. In this blog post, Dominic Warrino (KCAS; KS, USA), shares his insights into immuno-oncology, and discusses two case studies utilizing antibody drug conjugates and cellular therapies.
In this interview we talk to Timothy Olah (Bristol-Myers Squibb) about his research and role as Group Director. He discusses his group’s responsibility for developing quantitative methods to measure novel therapeutics and biomarkers in discovery.
Find out more about the validation of biomarkers in this interview with Hanna Ritzén, Managing Director Research and Development at Mercodia AB (Uppsala, Sweden).
To kick-start this special focus, we wanted to hear your thoughts on the topic – complete our short survey on the validation of biomarkers and be the first to receive our informative infographic collated from the survey results.
MetaboQuan-r for bile acids in human serum: a rapid, targeted UPLC-MS/MS method for metabolomic research studies
Bile acids are an important class of biological molecules that are generated in the liver and play a central role in various biological functions, including cholesterol homeostasis. Quantitative analysis for research of bile acids using LC-MS is complicated by the presence of many isomeric compounds.Historically, this has meant that throughput has been compromised in order to separate these isomeric compounds. Here we demonstrate how these compounds can be separated, without compromising throughput, using Waters® CORTECS UPLC Technology combined with negative mode electrospray ionization mass spectrometry. This application note is also part of a MetaboQuan-R method package.
In this Spotlight, we will be revisiting some of the key issues raised in a previous Spotlight: Biomarkers (and biosensors), as well as investigating advancements in the field and the development of techniques. We will hear from experts in the field about the key challenges they face, how they overcome them and how their research is helping to advance the development of human healthcare.