Webinar available to view on demand. This webinar talks about the benefit of incorporating microsampling techniques in bioanalytical assays, as well as the effort required to overcome the challenges.
Spotting of external calibration standards on blank dried blood spots as a resource-sparing protocol
Dried blood spots (DBS) offer significant ethical and scientific advantages. In this article the authors develop a methodology wherein small volumes of external calibration standards can be spiked on to blank DBS cards.
In this commentary, Melanie Anderson discusses the use of paper-based dried sampling technologies and how they can provide opportunities to collect biological samples in the dried state, which involves significantly smaller sample volumes than traditional sample collection approaches.
For therapeutic drug development and monitoring, microsampling technology provides a breakthrough alternative
One useful way to think about volumetric absorptive microsampling (VAMS) technology is as the next generation of traditional dried blood spot (DBS) cards. It’s a simpler method that makes it easier to collect blood and prepare it for analysis. With minimal training, the microsampling process can be self-administered anywhere, through a procedure that is less difficult and generally less expensive than working with conventional venous blood. Other benefits include a more pleasant patient experience, which leads to greater adherence and compliance, and freer access to remote areas of the world.
Volumetric absorptive microsampling and impact-assisted extraction: have we finally eliminated the hematocrit effect?
Altasciences’ experts share their most recent experience using Volumetric Absorptive Microsampling Mitra™ technology from product characterization to application development, highlighted with specific case studies.
Researchers have tested the efficacy of serum samples in comparison with dried blood spots when used in longitudinal studies.
In this Editorial, Tim Sangster takes a personal look at how microsampling has developed over the last couple of decades.
A DBS method for quantitation of the new oral trypanocidal drug fexinidazole and its active metabolites
The authors discuss the practicality of a novel DBS finger-prick sampling method and whether it offers a simple, practical method for determining FEX, M1 and M2 concentrations in clinical studies in Africa.
Take a look at our recent survey reviewing how attitudes towards microsampling has changed over the past 2 years since our Spotlight Microsampling – the road ahead.
In this paper, the authors describe a novel DBS–LC–MS/MS method that has been validated following international (US FDA and EMA) guidelines for bioanalytical method validation and the European Bioanalysis Forum recommendations for DBS analysis.