As part of our Spotlight on HRMS in DMPK, we carried out a survey to gain an insight into the trends, challenges and developments associated with using HRMS for DMPK studies. We would like to thank everyone who was able to share their thoughts by taking part in the survey – you can see the results below in our infographic.
Webinar now available on demand. The aim of DMPK is to enable scientists to learn the safety and efficacy of new molecular entities. HRMS is an important analytical tool used to study DMPK that continues to gain traction when quantifying molecules.
High-resolution mass spectrometry: an essential tool for DMPK studies of novel peptide-based modalities
In this editorial Simone Esposito (IRBM, Italy) explores how HRMS has become a well established alternative to multiple reaction monitoring for DMPK profiling and discusses the use of HRMS for DMPK studies of nove peptide-based modalities.
A collection of helpful answers to the most frequently asked questions concerning the use of high-resolution mass spectrometry (HRMS) in drug metabolism and pharmacokinetics (DMPK).
This poster from SCIEX (Warrington, UK) reports the use of an immunoaffinity high-resolution accurate mass assay as a complimentary analytical technique for signature peptide quantification.
This presentation from SCIEX (Warrington, UK) explores why we need high-resolution accurate mass spectrometry quantification, discussing topics ranging from the desire for higher selectivity in complex matrices to the need to analyze multiple charge states and fragment ions.
In this podcast, Szabolcs Szarka (Senior Scientist at LGC; Cambridgeshire, UK) discusses his use of HRMS and the benefits and challenges he has encountered in the field of pharmaceutical R&D and drug discovery. He also closes by offering his opinion on what he hopes the future may hold.
In this podcast, Jason Causon (Technical Product Manager at SCIEX, Canada) discusses his experience with HRMS and the current research focuses at SCIEX. He also details how SCIEX are using HRMS, the biggest challenges that have had to be overcome and future opportunities that he hopes HRMS software will bring.
In this series of short, recorded presentations a team from Waters (MA, USA) discuss fundamental and practical details regarding large molecule quantification.
In this podcast, Mark Wrona (Principal Scientist at Waters Corporation; MA, USA) discusses his experience with HRMS and the current trends in the field of DMPK.