Thermo Fisher Scientific (MA, USA) have announced the release of a new HPLC system as well as the launch of new chromatography data system software.
To get a better understanding of the bioanalytical applications of chromatography we interviewed Makoto Tsunoda (University of Tokyo, Japan). Makoto described his research developing analytical methods to quantify endogenous compounds in a range of complex matrices.
HPLC–MS/MS-based analysis of everolimus in rabbit aqueous humor: pharmacokinetics of in situ gel eye drops of suspension
Learn about the development of a robust HPLC-MS/MS method to determine the concentration of everolimus in the eye aqeuous humor and the future outlook for further research in this research article from Bioanalysis.
In this interview, Kevork Kalaydjian (ZefSci; QC, Canada) explores the changing perspectives towards cannabis and how bioanalytical scientists can help improve the understanding of the scientific benefits and limitations of cannabis and its derivatives.
Retention time bracketing for targeted sphingolipidomics by liquid chromatography–tandem mass spectrometry
Learn more about the potential impact of a retention time table and a list of appropriate standards as a resource for targeted sphingolipidomics in this article in Bioanalysis.
We talk to Laura Rowe about her work using UHPLC to analyse protein glycosylation in this interview as part of our author’s perspective series.
This review article from Bioanalysis> introduces the differences between UHPLC and HPLC, and reviews the use of UHPLC in the last 5 years when studying the glycosylation of proteins and glycoprofiling biopharmaceuticals.
Quantification of phenolic acid metabolites in humans by LC–MS: a structural and targeted metabolomics approach
In this research article from Bioanalysis, the authors quantified and identifed over 50 analytes from human biological matrices by HPLC, NMR and LC–MS to obtain structural information on phenolic acid metabolites.
Preclinical pharmacokinetics and biodistribution studies of asenapine maleate using novel and sensitive RP–HPLC method
This study investigates the pharmacokinetic and tissue distribution study of ASPM following oral administration in rats. Learn more in this study from Bioanalysis .
Researchers from the University of Colorado Anschutz Medical Campus (Aurora, Colorado, USA) have identified a biomarker in plasma that may serve as a predictor of epilepsy.