High-resolution mass spectrometry has come a long way since its inception. As the field continues to evolve, take a look at the applications of HRMS. From exact mass to routine analyses, what’s next?
In this In the Zone feature we put HRMS versus QqQ in a head to head comparison over a wide range of application areas. Find out the advantages and disadvantages of HRMS and QqQ for small and large molecule bioanalysis.
In this interview, Richard Kay (Wellcome Trust, University of Cambridge, UK) discusses his use of HRMS and QQQ for the analysis of the peptidome.
As part of our Spotlight on HRMS in DMPK, we carried out a survey to gain an insight into the trends, challenges and developments associated with using HRMS for DMPK studies. We would like to thank everyone who was able to share their thoughts by taking part in the survey – you can see the results below in our infographic.
Webinar now available on demand. The aim of DMPK is to enable scientists to learn the safety and efficacy of new molecular entities. HRMS is an important analytical tool used to study DMPK that continues to gain traction when quantifying molecules.
Join LGC scientists in the grudge match debate direct from Cambridge (UK) to decide the new king of quantitation.
This application note from Waters discusses a robust and reliable IA-LC-HRMS method for the qualitative analysis and quantification of ado-trastuzumab emtansine (T-DM1, Kadcyla™).
High-resolution mass spectrometry: an essential tool for DMPK studies of novel peptide-based modalities
In this editorial Simone Esposito (IRBM, Italy) explores how HRMS has become a well established alternative to multiple reaction monitoring for DMPK profiling and discusses the use of HRMS for DMPK studies of nove peptide-based modalities.
A collection of helpful answers to the most frequently asked questions concerning the use of high-resolution mass spectrometry (HRMS) in drug metabolism and pharmacokinetics (DMPK).
Complexity of human diseases should promote the use of high-resolution mass spectrometry for routine untargeted analyses
In this editorial Bertrand Rochat (University of Lausanne, Switzerland) discusses the developments in the field of HRMS over the last 2 decades and his hopes for the future use of HRMS in routine untargeted analysis.