Browsing: immunogenicity

Immunogenicity FEATURE_panel_jan_2019

Webinar live date: Thursday 10 January 2018 07:00 [PST] 10:00 [EST] 15:00 [GMT]. In this free panel discussion, our experts will provide insights into their own research with immunogenicity including the challenges they have had to overcome, key trends they have seen and their future outlook of the development of this field.

Immunogenicity FEATURE_KCAS_Jan_2019

Webinar live date: Monday 7 January 2019 07:00 [PST] 10:00 [EST] 15:00 [GMT]. This webinar will give an overview of immunogenicity assay development, explore the impact of anti-drug antibodies on bioanalysis and review relevant case studies discussing in-study cut-point and tolerance.

Immunogenicity Bz KCas image

Immunogenicity is the patient’s ability to generate antibodies, specific to the ‘dosed protein therapeutic’. In this blog post, Franklin Spriggs (KCAS; KS, USA) explains the importance of antibody-drug antibody assays and how data can be used towards safety profiles.

Immunogenicity Spotlight survey 1

To kick-start this our special focus on immunogencity, we wanted to hear your thoughts on the topic. Complete our short survey on immunogencity and be the first to receive our informative infographic collated from the survey results.

Immunogenicity Novel Approach to Immunogenicity Testing for Therapeutics

Developing Immunogenicity methods for patient populations with a high prevalence of pre-existing antibodies pose challenges that are difficult to validate. Care must be taken to acknowledge these risks during development of screening strategy and method development. In this case study, the therapeutic consisted of two domains (X-Y) in which domain X has homology to a childhood vaccine with known immunogenicity in ≥90% of the U.S. population. Screening strategy includes domain specificity testing using inhibition by excess of each domain for confirmatory cut point determination.

1 2 3