In this In the Zone feature we put HRMS versus QqQ in a head to head comparison over a wide range of application areas. Find out the advantages and disadvantages of HRMS and QqQ for small and large molecule bioanalysis.
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In this feature we explore how the adeno-associated virus has reinvigorated the field of gene therapy. We also explore the challenges developing gene therapies and the requirement for multi-tiered analysis approaches when assessing patient responses.
This In the Zone infographic explores the tools and techniques used during the AAV gene therapy development pathway, detailing processes from rAAV generation and in vitro and in vivo testing through to assessing the host immune response.
In this feature, we explore the key qualities to look for to ensure success when outsourcing immunogenicity assay development and testing. We also explore the methods for – and challenges involved with – T-cell immunity monitoring and assay development.
Assay development enables a drug or biochemical to be tested or measured. When analyzing a peptide of interest, it is important to choose and develop assays that are specific, sensitive and robust. There are many challenges when developing assays.
Bioanalysis is a critical part of the discovery and development of peptide therapeutics. In this In the Zone, we explore key bioanalytical challenges of peptide bioanalysis sample preparation.
In this feature, we will be investigating different alternative matrices that are available to the bioanalytical scientist and what questions need to be asked when deciding on the appropriate matrix to answer specific bioanalytical questions.
The future of alternative matrices in bioanalytical workflows: an interview with Amy Mize (KCAS Bioanalytical & Biomarker Services)
In this exclusive interview, Dr Amy Mize (KCAS Bioanalytical Services; KS, USA) describes how alternative matrices can be applied to bioanalytical studies and what challenges need to be addressed in order to introduce these matrices into bioanalytical workflows.
As part of our ‘In the Zone’ feature on drug metabolism, we present the top 6 tips for LC–MS for drug metabolism studies. Find out more about best practice tip and tricks for LC–MS in this helpful infographic from MilliporeSigma (MO, USA).
As part of our focus, we present this podcast where we talk to Mark Savage who discusses how software tools can address certain challenges and bring forward compounds from discovery to development.