Browsing: LC-MS

Proteomics Antibody-drug conjugates Featured
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Alternative scaffold proteins have emerged as novel platforms for development of therapeutic applications. One such application is in protein–drug conjugates, which are analogous to antibody–drug conjugates. Find out more in this research article from Bioanalysis.

News 2018 review feature image
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From the quantification and validation of biomarkers to the integration of novel technology in bioanalytical workflows, as the year comes to a close we’re looking back on the bioanalytical highlights from 2018.

spotlight Waters image for bz
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Bile acids are an important class of biological molecules that are generated in the liver and play a central role in various biological functions, including cholesterol homeostasis. Quantitative analysis for research of bile acids using LC-MS is complicated by the presence of many isomeric compounds.Historically, this has meant that throughput has been compromised in order to separate these isomeric compounds. Here we demonstrate how these compounds can be separated, without compromising throughput, using Waters® CORTECS UPLC Technology combined with negative mode electrospray ionization mass spectrometry. This application note is also part of a MetaboQuan-R method package.

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