Browsing: LC-MS

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Bioanalysis Zone and Bioanalysis welcome unsolicited submissions to both the journal and website!

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Bioanalysis Zone today announced the winner of the Bioanalysis Outstanding Contribution Award – BOSCA – awarded to bioanalytical scientists for outstanding work and contribution to the community.

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Issue 23 of Bioanalysis volume 9 is now available, including an editorial discussing the matrix effects, a methodology on assay signaling and a White Paper on the rise of hybrid LBA/LCMS immunogenicity assays.

MS (LC–MS/MS, HRMS, IMS) 1 EBF Trypsin poster-1
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Here we utilize a cysteine-linked antibody fluorophore conjugate to show how LC-MS methods may be optimized using a non-toxic ADC-mimic. The ADC-mimic was used to develop native and reduced SEC-MS conditions. The reduced mimic’s heavy and light chains, as well as its IdeS-proteolysis fragments, were used to develop reversed-phase LC-MS methods. A tryptic digest of the ADC mimic was used to develop a peptide mapping LC-MS method.

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