Discover more about new μFLC technologies that are providing discovery bioanalytical scientists with an effective strategy for method development and optimization in this article from Bioanalysis.
How to achieve sensitive and specific oligonucleotide quantification by hybrid immunoassay and LC–MS/MS
Webinar available to view on demand. Quantitative, sensitive and specific bioanalytical methods for the investigation of therapeutic oligonucleotides in biological matrices
An author’s perspective: Amanda King-Ahmad on quantitation of the peptide-1 receptor agonist liraglutide
We talk to Amanda King-Ahmad about her work on the peptide-based glucagon-like peptide-1 receptor agonist liraglutide in this interview as part of our author’s perspective series.
Combining LC–MS/MS and hollow-fiber infection model for real-time quantitation of ampicillin to antimicrobial resistance
In this research article from Future Science OA, the authors investigate antibiotic resistance in Escherichia coli, which causes most urinary tract infections, by quantifying ampicillin in real-time using a combined LC–MS/MS and hollow-fiber infection model.
Webinar available to view on demand. Learn how a standardized approach for the bioanalysis of biotherapeutics by hybrid LC–MS is applied in a contract research environment, whilst also considering compliance with regulatory requirements.
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How we can use the Xevo Mass Spectrometer, combined with immunoaffinity extraction to provide a premium sensitivity assay for our clients and help them drive forward the development of insulin molecules and their biosimilars?
Poster: A Highly Sensitive, Efficient and Robust LC-MS/MS Method for the Analysis of Encenicline (EVP-6124) and Two Metabolites in Human Plasma
Encenicline (EVP-6124), shown in Figure 1, is a potent orthosteric agonist of the α7 nicotinic acetylcholine receptor (α7 nAChR). This compound is being developed with the potential clinical indication
to treat cognitive impairment in patients with schizophrenia or Alzheimer’s disease (AD).
The primary circulating non-conjugated metabolites of encenicline are encenicline N-oxide, formed by oxidation of the quinuclidine nitrogen atom, and encenicline acid metabolite, a product formed through hydrolysis of an amide bond. Metabolite profiling has also indicated the presence of an N-glucuronide as well as other metabolites.
Liposomes, used as carriers for drug delivery, encapsulate and protect the therapeutic analytes from degration.…
A sensitive and accurate method to simultaneously measure uric acid and creatinine in human saliva by using LC–MS/MS
Read more about this study to establish a method to simultaneously measure uric acid and creatinine in human saliva, recently published in Bioanalysis.
Post-acquisition data mining techniques for LC–MS/MS-acquired data in drug metabolite identification
This review discusses the targeted and untargeted post-acquisition data mining techniques, which facilitate the drug metabolite identification. Learn more in this article from Bioanalysis.