SCIEX announces innovations in their ultra low-flow separation and accurate mass analysis, capillary electrophoresis–mass spectrometry (CESI-MS) technology and LGC announces investment plans in new GMP analytical capability.
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In this free panel discussion, our experts will provide insights into their own research with large molecules including the challenges they have had to overcome, key trends they have seen and their future outlook of the development of this field.
In this review from Bioanalysis, the authors concisely introduce coated blade spray’s operational fundamentals and to consider how it correlates/contrasts with existing direct-to-MS technologies suitable for bioanalytical applications.
We talk to Germán Augusto Gómez-Ríos about shifting the paradigm of direct sample introduction to MS.
We compared recombinant trypsin to native-source in various MS workflows.
Native source trypsin is dimethylated to prevent autolysis and TPCK treated to inhibit chymotrypsin.
Native and recombinant trypsins gave similar amounts of proteins and peptides identified in a complex mixture.
TIC of a single-protein digest revealed more complete peptide processing by recombinant trypsins relative to native trypsin.
Trypsin dimethylation leads to slower processing but with fewer autolytic peptides present.
Learn about the fundamentals of ion mobility mass spectrometry (IMS) and the benefits of collisional-cross…
Chromatography and electrospray ionization mass spectrometry utilized to determine specific lipid biomarkers for breast cancer.
In this research article the authors develop a UHPLC-MS/MS assay to quantify urinary dehydroepiandrosterone (DHEA), 7β-hydroxy-DHEA, cortisone and 6β-hydroxycortisone as potential biomarkers to predict CYP3A activity.
A team of computer scientists have developed a new method identifying new antibiotic compounds from previously unexplored mass spectrometry data.
New diagnostic test for cocaine developed by researchers from the University of Surrey’s Department of Chemistry (UK).
