This poster from SCIEX (Warrington, UK) reports the use of an immunoaffinity high-resolution accurate mass assay as a complimentary analytical technique for signature peptide quantification.
This presentation from SCIEX (Warrington, UK) explores why we need high-resolution accurate mass spectrometry quantification, discussing topics ranging from the desire for higher selectivity in complex matrices to the need to analyze multiple charge states and fragment ions.
A new study from the University of Texas at Austin (TX, USA) reports a desorption electrospray ionization mass spectrometry-based technique that could improve clinical thyroid cancer diagnosis.
Learn about a method for determining breath acetone concentration using direct breath sampling and system-proton transfer reaction MS in this research article from Bioanalysis.
SCIEX announces innovations in their ultra low-flow separation and accurate mass analysis, capillary electrophoresis–mass spectrometry (CESI-MS) technology and LGC announces investment plans in new GMP analytical capability.
Available to view on demand.
In this free panel discussion, our experts will provide insights into their own research with large molecules including the challenges they have had to overcome, key trends they have seen and their future outlook of the development of this field.
In this review from Bioanalysis, the authors concisely introduce coated blade spray’s operational fundamentals and to consider how it correlates/contrasts with existing direct-to-MS technologies suitable for bioanalytical applications.
We talk to Germán Augusto Gómez-Ríos about shifting the paradigm of direct sample introduction to MS.
We compared recombinant trypsin to native-source in various MS workflows.
Native source trypsin is dimethylated to prevent autolysis and TPCK treated to inhibit chymotrypsin.
Native and recombinant trypsins gave similar amounts of proteins and peptides identified in a complex mixture.
TIC of a single-protein digest revealed more complete peptide processing by recombinant trypsins relative to native trypsin.
Trypsin dimethylation leads to slower processing but with fewer autolytic peptides present.
Learn about the fundamentals of ion mobility mass spectrometry (IMS) and the benefits of collisional-cross…
