Webinar available to view on demand. This webinar talks about the benefit of incorporating microsampling techniques in bioanalytical assays, as well as the effort required to overcome the challenges.
Optimizing NBE PK/PD assays using the Gyrolab Affinity Software; conveniently within the bioanalyst’s existing workflow
Learn about the optimization of NBE PK/PD assays utilizing the Gyrolab Affinity Software and find out more about the author in this journal article from Bioanalysis.
Read time: 3 mins
We talk to Maria Myzithras about Optimizing NBE PK/PD assays using the Gyrolab Affinity Software following her latest publication in Bioanalysis.
Read more about the valdiation of an ELISA to investigate the pharmacokinetics and concentration–response relationship of panitumumab, in this article from Bioanalysis.
Spotting of external calibration standards on blank dried blood spots as a resource-sparing protocol
Dried blood spots (DBS) offer significant ethical and scientific advantages. In this article the authors develop a methodology wherein small volumes of external calibration standards can be spiked on to blank DBS cards.
Issue 20 of Bioanalysis volume 9 is now available, including an editorial surrounding the factors which may impact PK measurements of antibody therapeutics alongside the latest methodologies, research articles and discussions of current bioanalytical challenges. Find out more about the issue here, or on the Bioanalysis webpage.
Preclinical pharmacokinetics and biodistribution studies of asenapine maleate using novel and sensitive RP–HPLC method
This study investigates the pharmacokinetic and tissue distribution study of ASPM following oral administration in rats. Learn more in this study from Bioanalysis .
For therapeutic drug development and monitoring, microsampling technology provides a breakthrough alternative
One useful way to think about volumetric absorptive microsampling (VAMS) technology is as the next generation of traditional dried blood spot (DBS) cards. It’s a simpler method that makes it easier to collect blood and prepare it for analysis. With minimal training, the microsampling process can be self-administered anywhere, through a procedure that is less difficult and generally less expensive than working with conventional venous blood. Other benefits include a more pleasant patient experience, which leads to greater adherence and compliance, and freer access to remote areas of the world.
Boehringer Ingelheim has announced that the interchangeability study for their adalimumab biosimilar candidate has begun.
Current thinking on quantification of protein therapeutic pharmacokinetics and protein biomarkers in clinical studies
In this commentary, Kate Peng discusses the current thinking on quantification of protein therapeutic pharmacokinetics and protein biomarkers in clinical studies.