This article from Bioanalysis is focused on the challenges in the development of flow cytometry bioanalytical methods to quantitatively measure CAR-T cell levels in adoptive cell therapy.
We talk to Vellalore Kakkanaiah about his work using flow cytometry in adoptive cell therapy in this interview as part of our author’s perspective series.
Webinar available to view on demand. Methods for the detection of drug-induced antibodies have become much more sensitive, but the question remains to be answered: are antibodies at this low concentration level clinically relevant?
Webinar available to view on demand. In this webinar, our Bioanalysis Zone Rising Star Award winner, Jing Tu (PPD; VA, USA), will introduce a systematic approach that allows efficient and consistent ligand binding based bioanalytical method development.
Webinar available to view on demand. This webinar talks about the benefit of incorporating microsampling techniques in bioanalytical assays, as well as the effort required to overcome the challenges.
Optimizing NBE PK/PD assays using the Gyrolab Affinity Software; conveniently within the bioanalyst’s existing workflow
Learn about the optimization of NBE PK/PD assays utilizing the Gyrolab Affinity Software and find out more about the author in this journal article from Bioanalysis.
Read time: 3 mins
We talk to Maria Myzithras about Optimizing NBE PK/PD assays using the Gyrolab Affinity Software following her latest publication in Bioanalysis.
Read more about the valdiation of an ELISA to investigate the pharmacokinetics and concentration–response relationship of panitumumab, in this article from Bioanalysis.
Spotting of external calibration standards on blank dried blood spots as a resource-sparing protocol
Dried blood spots (DBS) offer significant ethical and scientific advantages. In this article the authors develop a methodology wherein small volumes of external calibration standards can be spiked on to blank DBS cards.
Issue 20 of Bioanalysis volume 9 is now available, including an editorial surrounding the factors which may impact PK measurements of antibody therapeutics alongside the latest methodologies, research articles and discussions of current bioanalytical challenges. Find out more about the issue here, or on the Bioanalysis webpage.