In this interview we caught up with Hua Li (Boehringer Ingelheim Pharmaceuticals, CT, USA) to discuss her research and the inspiration for her 2018 Bioanalysis publication concerning the use of Mitra® microsampling for PK bioanalysis of monoclonal antibodies.
A collaborative team of researchers based at the Wyss Institute (Harvard University, MA, USA) has developed linked organ-on-a-chip systems that could be used to quantitatively predict drug pharmacokinetics, addressing some of the limitations of preclinical studies.
Available on demand. LC–MS based large molecule bioanalysis platform was developed, validated and applied for drug screening and preclinical pharmacokinetics.
In this interview, Annick De Vries (Sanquin; Amsterdam, Netherlands) discusses how personalized sampling can be utilised to achieve optimal PK/PD data, and how PK measurements translate into real life.
In this report from Bioanalysis, the authors summaries key points discussed the Bioanalysis Zone panel discussion filmed during the 12th Workshop on Recent Issues in Bioanalysis which focused on the topic of new technology integration into bioanalytical workflows.
Receptor occupancy measurement by flow cytometry is a rapid, quantifiable and an important addition to PK and PD data in the biopharmaceutical development process.
This article from Bioanalysis is focused on the challenges in the development of flow cytometry bioanalytical methods to quantitatively measure CAR-T cell levels in adoptive cell therapy.
We talk to Vellalore Kakkanaiah about his work using flow cytometry in adoptive cell therapy in this interview as part of our author’s perspective series.
Webinar available to view on demand. Methods for the detection of drug-induced antibodies have become much more sensitive, but the question remains to be answered: are antibodies at this low concentration level clinically relevant?
Webinar available to view on demand. In this webinar, our Bioanalysis Zone Rising Star Award winner, Jing Tu (PPD; VA, USA), will introduce a systematic approach that allows efficient and consistent ligand binding based bioanalytical method development.