In this free on demand panel discussion, our experts provide insights into their own research with cellular and gene therapies including the challenges they have had to overcome, key trends they have seen and their future outlook of the development of this field.
Application of Mitra® Microsampling for Pharmacokinetic Bioanalysis of Monoclonal Antibodies in Rats
In this methodology article from Bioanalysis, H Li et al. describe the use of the Mitra® microsampler for blood sampling, ELISA quantitation and PK analysis of two marketed therapeutic monoclonal antibodies administered to rats.
Webinar available to view on demand. Learn how a standardized approach for the bioanalysis of biotherapeutics by hybrid LC–MS is applied in a contract research environment, whilst also considering compliance with regulatory requirements.
In this interview Alex Hawes (LGC; Cambridge, UK) discusses the topic of immunogenicity. She explains how she developed her first anti-drug antibody analytical method and the platforms LGC use in their immunogenicity sector.
Find out more about the technologies involved in drug metabolism and what the future may hold for drug metabolism studies in drug discovery research in this ‘In the Zone’ feature.
Optimizing NBE PK/PD assays using the Gyrolab Affinity Software; conveniently within the bioanalyst’s existing workflow
Learn about the optimization of NBE PK/PD assays utilizing the Gyrolab Affinity Software and find out more about the author in this journal article from Bioanalysis.
Read time: 3 mins
We talk to Maria Myzithras about Optimizing NBE PK/PD assays using the Gyrolab Affinity Software following her latest publication in Bioanalysis.
Implementing a tiered approach to bioanalytical method validation for large-molecule ligand-binding assay methods in pharmacokinetic assessments
Bioanalytical methods must enable the delivery of data that meet sound, scientifically justified, fit-for-purpose criteria. This perspective piece highlights three tiers of method validation – regulatory, scientific and research validations. The criteria for selecting the appropriate application of each of these PK method validation workflows are discussed.
In this commentary, Melanie Anderson discusses the use of paper-based dried sampling technologies and how they can provide opportunities to collect biological samples in the dried state, which involves significantly smaller sample volumes than traditional sample collection approaches.
Biocompatible Solid Phase Micro Extraction (BioSPME): A Tool to Overcome Matrix Effect for Multi-Class Compound Methods
Biocompatible solid phase micro extraction (BioSPME) is a sample preparation method that allows for the extraction of various analytes of interest from complex biological matrices without significant co-extraction of common interferences including salts, proteins, and phospholipids. Analytes can be recovered by simply desorbing within an organic solvent prior to analysis. Significant reduction in matrix interferences allows the user to focus on the separation of analytes during method development.