To provide remote support for sites and patients enrolled in clinical trials, PRA Health Sciences (NC, USA) has expanded its mobile health platform. New capabilities could help to address sponsor needs for virtual support during the global COVID-19 pandemic.
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Collaboration in action: Nepali chemist receives 10 week bioanalytical training at three Dutch CRO’s
A Chemist and Quality Control Manager from a Nepali pharmaceutical company receives full training in bioanalytical method development and validation.
This infographic presents key results from the large molecule quantification by LC–MS survey.
Poster: A Highly Sensitive, Efficient and Robust LC-MS/MS Method for the Analysis of Encenicline (EVP-6124) and Two Metabolites in Human Plasma
Encenicline (EVP-6124), shown in Figure 1, is a potent orthosteric agonist of the α7 nicotinic acetylcholine receptor (α7 nAChR). This compound is being developed with the potential clinical indication
to treat cognitive impairment in patients with schizophrenia or Alzheimer’s disease (AD).
The primary circulating non-conjugated metabolites of encenicline are encenicline N-oxide, formed by oxidation of the quinuclidine nitrogen atom, and encenicline acid metabolite, a product formed through hydrolysis of an amide bond. Metabolite profiling has also indicated the presence of an N-glucuronide as well as other metabolites.
At PRA Health Sciences, we recognize that the world of clinical development is complex and dynamic, and we’ve designed our bioanalytical laboratories to meet those challenges. Proactive and always looking to the future, we provide the technology, innovative approaches, and high scientific standards required to deliver industry-leading laboratory servic
In our interview Chad talks about his career highlights, advice that he would share with his younger self about patience, and how his bioanalytical hero has helped in pushing him towards his goals.