Current methods for the treatment of cancer include radiation, chemotherapy and surgical intervention, but alternative treatment modalities exist should these traditional methods prove unsuccessful. In this blog post, Dominic Warrino (KCAS; KS, USA), shares his insights into immuno-oncology, and discusses two case studies utilizing antibody drug conjugates and cellular therapies.
Opportunities and challenges for hybrid immunoaffinity LC–MS approach for quantitative analysis of protein biomarkers
Learn more about opportunities and challenges for hybrid immunoaffinity LC–MS approach for quantitative analysis of protein biomarkers in this article from Future Science OA.
Introduction Low sensitivity methods in protein LC–MS bioanalysis commonly utilise a ‘bottom-up’ approach. However, lack…
In this application note, Yun Alelyunas (Waters Corporation) describes an LC-HRMS method for high sensitivity bioanalysis of monoclonal antibodies by direct mass measurement at the intact level for whole molecule quantification. This emerging approach can serve as an alternative or complement to traditional methods such as ligand binding assay for protein quantification. Methodology and guidance for evaluating and optimizing data processing parameters are discussed in detail.
Waters’ team of bioanalysis experts developed the Peptide & Protein Bioanalysis Boot Camp – a…
Developing novel methods for protein, peptide and metabolite analysis: an interview with Rainer Bischoff
Watch time: 6:47 mins
Rainer Bischoff (University of Groningen; Groningen, The Netherlands) explains his current research focus with an emphasis on developing novel methods for protein, peptide and metabolite analysis in this video interview.
Immunogenicity of therapeutic protein products: current considerations for anti-drug antibody assay in Japan
In this review, the authors introduce the current situation regarding the development and immunogenicity assessment of therapeutic protein products in Japan. Then they present their view and recommendations on the ADA assay by considering its unique features.
Researchers have developed a quantitative immunochromatographic test, with a new type of membrane test strip, which could aid the early diagnosis of heart attack by identifying markers in blood.
Lonza (Basel, Switzerland) announce the launch of four new services to expand their early phase biopharmaceutical drug development.
Researchers have identified a protein that could aid in preventing, treating and even reversing alcoholic liver damage.