Expand your lab’s capabilities and rapidly increase coverage of a variety of in-demand metabolomics and lipid assays, while significantly reducing development times and the operating costs of running a wide range of assays. The Waters Targeted Omics Library, including the MetaboQuan-R and LipidQuan-R Rapid Targeted Omics Method packages, is an on-line database of method files and application notes for a variety of in-demand metabolite and lipid panels.
Find out more about some of the top stories this week in methodological improvements for the quantitative analysis of proteomes, and for the production of chiral molecules.
Read time: 2 mins
Read more about the latest advances in proteomics this week in our themed weekly news round-up, including news regarding a new clinical market license for a predictive diagnostic test for diabetic kidney disease, and a new device for in vivo real-time proteomics in surgical oncology.
Assessing a multiplex targeted proteomics approach for the clinical diagnosis of periodontitis using saliva samples
This study from Bioanalysis focused on the research of new biomarkers based on the liquid chromatography-multiple-reaction monitoring (MRM) proteomic profile in whole saliva.
A research team from Brazil has combined two techniques to identify over 10, 000 proteins expressed in oligodendrocytes in an effort to better understand the causes of schizophrenia.
Evaluation of Recombinant, Chemically Treated Trypsin in Proteomics and Protein Characterization Assays
We compared recombinant trypsin to native-source in various MS workflows.
Native source trypsin is dimethylated to prevent autolysis and TPCK treated to inhibit chymotrypsin.
Native and recombinant trypsins gave similar amounts of proteins and peptides identified in a complex mixture.
TIC of a single-protein digest revealed more complete peptide processing by recombinant trypsins relative to native trypsin.
Trypsin dimethylation leads to slower processing but with fewer autolytic peptides present.
Webinar Q and A follow up: Practical considerations in the design of quantitative targeted methods in proteomics
Follow-up of the live webinar Q and A session
In this mini-webinar you will learn about different LC-MS/MS approaches for quantitative protein bioanalysis with focus on biopharmaceuticals, biomarkers and targeted proteomics.
Attendees will learn our laboratory’s approach for designing, calibrating, and implementing protein quantitation assays in proteomics.
Metabolomic profiling could allow identification of cancer subtypes and precision therapy.