Brendan Griffin (University College Cork, Ireland) discusses his work in early drug development in this interview with Bioanalysis Zone. Brendan talks about the most common challenges faced as well as key trends in the field of developability.
Neil Spooner, Senior Editor of Bioanalysis and Founder and Director of Spooner Bioanalytical Solutions (Hertford, UK), discusses recent technological advances and current regulatory perspectives on patient-centric sampling approaches.
Electromembrane extraction of substances with weakly basic properties: a fundamental study with benzodiazepines
In this article from Bioanalysis, researchers investigated an electromembrane extraction method for weakly basic benzodiazepines. Results from the electromembrane extraction method followed by UHPLC-MS/MS analysis for human plasma samples were in compliance with EMA guidelines.
Mitigating target interference in bridging immunogenicity assay with target-blocking reagents and mild basic pH
It is documented that soluble drug targets in clinical study samples have generated false positive results in anti-drug antibody bridging assays due to target-mediated bridging. In this research paper read about strategies to mitigate target interference.
Author Montserrat Carrasco-Triguero (Genentech, CA, USA) gives us an insight into her research career and her paper published in Bioanalysis: Immunogenicity of antibody–drug conjugates: observations across 8 molecules in 11 clinical trials, in this author’s perspective feature.
Internal standards in regulated bioanalysis: putting in place a decision-making process during method development
In this perspective article from Bioanalysis the authors explore key considerations when selecting an IS and propose experiments to perform within the method development phase to demonstrate suitability of the IS within the assay prior to validation.
In this set of answers, Bioanalysis Zone address some of the FAQs regarding bioanalysis, what it is, what it entails and what it means to be a bioanalyst.
One of the most common issues introduced to primary care clinics is low back pain.…
Aston University (Birmingham, UK) has announced the installation of the Waters (MA, USA) SELECT SERIES Cyclic™ ion mobility spectrometry mass spectrometer, the first commercial research installation of an instrument of its kind.
The first method for determination of lipoyllysine in human urine after oral lipoic acid supplementation
Lipoic acid supplementation is known to have a prophylactic affect on many diet-realted diseases. This research article from Bioanalysis reports the first method to determine lipoyllysine levels in human urine following lipoic acid supplementation.