Researchers have developed a new microfluidic device that enables simultaneous double sorting and purification of target cells.
Browsing: sample preparation
In this latest instalment of our column from the Mass Spectrometry Research Center at Vanderbilt University, Danielle Gutierrez discusses techniques for membrane protein preparation for IMS.
In this article Erin Chambers (Waters Corporation) provides analytical considerations for large molecule LC-MS assays, based on the culmination of Waters experiences as well as those of the broader research industry. The considerations are segmented into liquid chromatography (LC), mass spectrometry (MS), and sample preparation.
LC-MS quantification of Trastuzumab using pellet digestion and ProteinWorks eXpress Direct Digest Kits
In this technology brief the authors describe a robust and reproducible pellet digestion and LC-MS/MS methodology to quantify the monoclonal antibody trastuzumab.
Simple, standardized, and sensitive quantification of Bevacizumab (Avastin) using ProteinWorks eXpress Digest Kits
This application note describes the fast, sensitive quantification of bevacizumab from rat plasma using the…
A generic kit-based approach for quantifying monoclonal antibody drugs through direct digestion of discovery study samples
In this application note, we have used the ProteinWorks™ eXpress Direct Digest Kit to simplify and streamline the workflow process using the same universal protocol and reagents for all monoclonal antibody drugs tested.
This infographic presents key results from the Large molecule analysis by LC-MS Spotlight survey.
This guide shares what Waters have learned from working with peptides at each point in the workflow, providing best practices for the analysis of peptides by LC-MS
Benefits of differential ion mobility spectrometry for high-sensitivity quantification of peptides in complex matrices
This webinar highlights how a simple orthogonal separation strategy can improve selectivity and sensitivity during biotherapeutic analysis of large peptide therapeutics.
Minimalistic sample preparation strategies for LC–MS quantification of large molecule biopharmaceuticals: a case study highlighting alpha-1 antitrypsin protein
In this Research Article two sensitive and selective LC–MS/MS-based quantification assays are developed to demonstrate a minimalistic sample preparation strategy for developing PK or biomarker quantification assays to support large-biomolecule drug-discovery efforts.