Browsing: Waters

Validation of biomarkers science petry dish

Biomedical research is largely centered on making new discoveries as it relates to human health and disease. The ultimate goal is to understand how human biology works and when and why it goes awry. With a strong foundation on the mechanisms of health and disease, advances in diagnostics and therapeutic interventions can be generated bringing cures to recalcitrant diseases such as cancer and neurodegenerative pathologies.

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In this feature, we present a collection of resources focusing on the ‘hot topic’ of biotransformation, including: an introduction to what it is, a podcast discussing the technologies used to characterize biotransformation and an infographic with our top 5 challenges for the biotransformation scientist and software solutions.

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Bile acids are an important class of biological molecules that are generated in the liver and play a central role in various biological functions, including cholesterol homeostasis. Quantitative analysis for research of bile acids using LC-MS is complicated by the presence of many isomeric compounds.Historically, this has meant that throughput has been compromised in order to separate these isomeric compounds. Here we demonstrate how these compounds can be separated, without compromising throughput, using Waters® CORTECS UPLC Technology combined with negative mode electrospray ionization mass spectrometry. This application note is also part of a MetaboQuan-R method package.

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Expand your lab’s capabilities and rapidly increase coverage of a variety of in-demand metabolomics and lipid assays, while significantly reducing development times and the operating costs of running a wide range of assays. The Waters Targeted Omics Library, including the MetaboQuan-R and LipidQuan-R Rapid Targeted Omics Method packages, is an on-line database of method files and application notes for a variety of in-demand metabolite and lipid panels.

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