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Featured ArticleRecent advances in metabolite identification and quantitative...Read more Featured NewsEBF announce ‘Old Battles and New Horizons’Read more Featured ArticleDevelopment of a method by UPLC–MS/MS for the quantification of...Read more
Featured NewsResearchers develop multiscale, donor-specific simulation of blood...Read more Featured ArticleBioanalysis of biotherapeutic proteins and peptides: immunological or...Read more

Featured Articles

Bioanalysis Young Investigator: Eugene CiccimaroEugene Ciccimaro Position: Applications Specialist; PhD: Pharmacology; Research area: Quantitative Proteomics and Metabolomics; Thermo Scientific, 265 Davidson Ave, Somerset, NJ 08873, USA. Ian A...

Bioanalysis Young Investigator: Michael GroesslMichael Groessl Position: Research Associate; PhD: Chemistry; Research area: Bioanalytical Chemistry; Max Planck Institute of Molecular Cell Biology & Genetics, Pfotenhauerstr. 108, 01307...

Recent advances in metabolite identification and quantitative bioanalysis by...The need for rapid, sensitive and effective identification and quantitation of drugs and metabolites to accelerate drug discovery and development has given MS its central position in drug metabolism...

Development of a method by UPLC–MS/MS for the quantification of...Background: Nitazoxanide (NTZ) is used for the treatment of gastrointestinal tract colonization by anaerobic bacteria, viruses and other pathogens that represent a major cause of morbidity in Latin...

Bioanalysis of biotherapeutic proteins and peptides: immunological or MS...Historically, the bioanalysis of proteins and peptides has been performed using immunological-based techniques. However, continued improvements in MS-based methodologies over the past 10 years have...

European Medicines Agency guideline on bioanalytical method validation: what...The European Medicines Agency (EMA) published a draft guideline on bioanalytical method validation in November 2009 (hereafter referred to as the ‘Guideline’) and following a consultation...

Fast chromatography in the regulated bioanalytical environment: sub-2-µm...Several companies have recently experienced, or will soon experience, patent expirations that will hurt profits and are looking for faster and cheaper ways to develop their pipelines to compensate...

Recent advances in column switching sample preparation in bioanalysisColumn switching techniques, using two or more stationary phase columns, are useful for trace enrichment and online automated sample preparation. Target fractions from the first column are...

Challenges in developing an ultra-sensitive bioanalytical method for...Background: Ethinylestradiol (EE) is the active component in most birth control products. It is especially difficult to analyze due to the presence of many closely related endogenous steroids....

New methodology for the development of chromatographic methods with...Bioanalytical methods are developed in order to answer the analytical problems faced by analysts. The analytical issues that must be solved are generally the detection and/or quantification of an...

Conference Report: Advances in Metabolic ProfilingThe main topics of this conference were based around new technologies and applications of metabolomics in healthcare, bioscience and environmental applications. There were sessions themed on...

Recent advances in liquid microextraction techniques coupled with MS for...Sample preparation is an important and necessary step in a measurement process for isolation and concentration of desired components from complex matrices. It is the most time-consuming and...

Quantitation of polypeptides (glucagon and salmon calcitonin) in plasma samples...Background: Bioanalysis of large molecules can be challenging on LC–MS/MS due to multiply charged and endogenous interferences. While high sensitivity triple quadrupole systems (QqQ) have been...

Letter to the Editor: Response to: Commentary on the history and quantitative...

Letter to the Editor: Commentary on the history and quantitative nature of...It is with great interest that we read Peter T Kissinger’s commentary about the use of dried blood spots (DBS) for pharmacokinetic assays and therapeutic drug monitoring published in the...

Combining label-free technologies: discovery in strengthSince the early 1990s when Biacore entered the market with the introduction of surface plasmon resonance (SPR) for use in elucidating interactions of proteins, label-free technologies have gained...

Recommendations on the interpretation of the new European Medicines Agency...Senior representatives of GCC member companies have thoroughly evaluated and discussed the new European Medicines Agency (EMA; July 2011 [1]) Guideline on Bioanalytical Method Validation (BMV),...

Conference Report: ‘Less is More’: defining modern bioanalysisThe 4th Open Symposium of the European Bioanalytical Forum entitled ‘Less is More’ was held on 16–18 November 2011 at the Hesperia Tower Hotel, Barcelona, Spain. More than 50...

Conference Report: ‘Large Meets Small’: connecting the...This conference report provides an overview of the discussions at the 2nd European Bioanalysis Forum (EBF) Focus Meeting ‘Large Meets Small’ held on 20 and 21 June 2011 in Brussels. The...

Interview with Christophe P. Stove (Ghent University) – DBS in toxicologyThe Laboratory of Toxicology research group at the Faculty of Pharmaceutical Sciences of Ghent University (Ghent, Belgium) have recently published a paper providing an overview of the different DBS...

Breaking News

Researchers have visualized acetylcholine distribution using imaging MSA team of Japanese scientists has revealed the localization of acetylcholine in the central nervous system tissue using imaging MS.

New biologics and biocomparables guidelines are now effective in MexicoNew guidelines are now in place for the marketing authorization of biologics and biocomparables in Mexico.

Cetero reaches a resolution with the US FDAAfter months of collaboration, the research organization finally resolves allegations of professional misconduct with the US FDA.

BASi adds director of discovery services, expands West Lafayette research...

The use of automation in the analysis of tyrosine kinase inhibitorsScientists develop automated technology to allow high-throughput therapeutic drug monitoring.

PathXL awarded Enabling Technology AwardBiomarker discovery enabling tool proves highly successful.

Researchers bring a breath of fresh air to disease diagnosticsA US research team has developed an instrument that could diagnose diseases by detecting biomarkers in the user’s breath.

Biotechnology Industry Organizaiton comments on FDA’s biosimilar draft...Biotechnology Industry Organization comments on the three biosimilar draft guidances issued earlier this year.

Collaboration aims to develop new cancer diagnostics biomarker discovery...The EU-funded Eurostars project will focus on a prototype platform to monitor protein/peptide degradation patterns in tissue and biological fluids.

EBF announce ‘Old Battles and New Horizons’Regulated bioanalysis – established concepts and recent thinking – will be the hot topic of discussion at the EBF 5th Open Symposium in November 2012.

Researchers develop multiscale, donor-specific simulation of blood functionA team of biomedical engineers and hematologists have developed a multiscale, patient-specific simulation of blood function.

The Kennedy Institute of Rheumatology at Oxford University and Novo Nordisk...Research will see collaboration between industry and academia for automimmune inflammatory diseases.

Harry Potter and the paper-based blood testAustralian research team publish their work on a novel test that spells out the result.

Protease cleavage lights up nanoparticleGroup develop nanoparticle that luminesces due to protease cleavage.

Metabolon and Takeda join forces to accelerate biomarker discoveryMetabolon and Takeda are to form a multiyear research collaboration for the discovery of therapeutic targets and biomarkers.

GSK bid US$2.6 billion to acquire Human Genome SciencesGSK’s bid of US$2.6 billion to aquire Human Genome Sciences is rejected.

Team develop biomarker to monitor seasonal allergic rhinitis treatment effectsResearchers at the Louis Bolk Institute, The Netherlands, have computed three robust systems-biology orientated biomarkers to detect the effectiveness of seasonal allergic rhinitis treatments.

Domino chip launches Aquila to final stage of business awardsA plastic chip developed by Canadian researchers could offer fast, cheap and portable pharmacogenomic testing.

Doubling-up: new serological bead-based assay detects simultaneous response of...Scientists develop new assay to detect antibody response for two parasites commonly found in infected pig serum.

Boost for tuberculosis researchThe Grand Challenges tuberculosis biomarkers program awards grants to ten research groups.

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Global CRO Council for Bioanalysis (GCC)The GGC have recently published a White Paper on the new EMA (July 2011) Guideline on Bioanalytical Method Validation (BMV)....

DBS in toxicologyChristophe Stove from Ghent University has recently delivered his opinions on the future and direction of DBS in the field...

Green bioanalytical chemistryThe future of green analytical chemistry and its relevance to the bioanalytical community is an important topic, with...

Crystal City V - will you be there?The original Crystal City bioanalysis workshops were over major importance to the development of regulated bioanalysis, as...

Hello and welcome to the new Bioanalysis Forum!!Please have a look around and tell us what you think, have a go at responding to this post or commenting on another users...

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