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0Derivatization methods for quantitative bioanalysis by LC–MS/MS

In this review researchers at the Chinese Academy of Sciences cover the derivatization strategies for the LC–MS analysis of various endogenous compounds. The authors also provide applications highlighting the impact of these important techniques in the evaluation of pathological events.

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0Update on Chinese Regulated Bioanalysis

In this article the China Bioanalytical Forum (CBF) provides an update on the Chinese bioanalytical regulatory landscape, discussing the emergence of recent changes in regulated bioanalysis.

Automation

Automation in Chinese bioanalytical CROs for sustained competitiveness and growth

Small-molecule bioanalytical sample preparation method development starting from the BASICS

Online and automated sample extraction

Chromatography

Interview with Xiwei (Emmi) Zheng (winner of the 2015 YIA) and Kelly Doering (Waters Corporation) on Young Investigator Award and the importance of supporting early career scientists

Press release: High-Pressure Ion Chromatography System delivers new levels of simplicity and flexibility

Derivatization methods for quantitative bioanalysis by LC–MS/MS

Clinical

The 2nd China Bioanalysis Forum Annual Conference: clinical bioanalysis and large molecule bioanalysis

2015 EBF Open Meeting video interviews

Interview with Kelly Colletti (Charles River) on Charles River's global clinical working group

Collaborations and Mergers

Building partnerships with other CROs

Introducing our Quality Assurance feature in collaboration with the SQA BASS

Press release: Envigo opens its doors for business on 21 September

Data Processing / Interpretation

Automation in Chinese bioanalytical CROs for sustained competitiveness and growth

Development of an Excel-based laboratory information management system for improving workflow efficiencies in early ADME screening

Proposal for a harmonized descriptive analyte nomenclature for quantitative large-molecule bioanalysis

Drug Discovery and Development

Update on Chinese Regulated Bioanalysis

The 2nd China Bioanalysis Forum Annual Conference: clinical bioanalysis and large molecule bioanalysis

The 3rd China Bioanalysis Forum annual meeting

Forensic

Fingerprints: biological samples for identification of sex and, potentially, more

Method developed to uncover the age of a fingerprint

Technique may allow forensic scientists to distinguish between identical twins’ DNA

Imaging

Researchers develop new technique to enhance digital microscopy images

A perspective through time: the history of imaging mass spectrometry and its potential for improved clinical outcomes

Future directions of imaging MS in pharmaceutical R&D

Ligand-binding

Highly specific and sensitive immunoassay for the measurement of prostaglandin E2 in biological fluids

Interview with Nico van de Merbel (PRA Health Sciences) on the regulatory challenges faced by bioanalytical laboratories and developments in the relationships between LBA and LC-MS scientists

2015 EBF Open Meeting video interviews

Mass Spectrometry

Derivatization methods for quantitative bioanalysis by LC–MS/MS

Interview with Peter Ketelaar (PRA Health Sciences) on why EBF is a great event for the bioanalytical community and PRA’s new state-of-the-art laboratory in Assen, the Netherlands

Interview with Nico van de Merbel (PRA Health Sciences) on the regulatory challenges faced by bioanalytical laboratories and developments in the relationships between LBA and LC-MS scientists

Other

Proteins detected by synthetic antibody

Novel biosensor developed using magnetic nanoparticles

Interview with Peter Ketelaar (PRA Health Sciences) on why EBF is a great event for the bioanalytical community and PRA’s new state-of-the-art laboratory in Assen, the Netherlands

Regulated Bioanalysis

Update on Chinese Regulated Bioanalysis

The 2nd China Bioanalysis Forum Annual Conference: clinical bioanalysis and large molecule bioanalysis

The 3rd China Bioanalysis Forum annual meeting

Sample preparation, extraction & collection

Improved sample tracking with novel Barcoded Latch Rack and Wireless Barcode Reader

Assay development for determination of tenofovir in human plasma by solid phase analytical derivatization and LC–MS/MS

Minimalistic sample preparation strategies for LC–MS quantification of large molecule biopharmaceuticals: a case study highlighting alpha-1 antitrypsin protein

Sports Drug Testing

Reining in doping in the horse racing industry

Current status and recent advantages in derivatization procedures in human doping control

Seven new metabolites of anabolic steroid identified

Toxicology

Interview with Tim Sangster and Kurt Sales (Charles River Laboratories) on the developing CRO industry and the challenges faced by sponsors

Press release: Galderma and ImaBiotech develop a long-term alliance to access Multimaging™ services

MALDI-MS offers new approach to cellular toxicity assays