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0Starting a CRO on personal credit

Read the first installment of Afshin Safavi’s (Founder & Chief Scientific Officer, BioAgilytix) column focusing on running a CRO. In this article Afshin discusses how he started BioAgilytix and provides top tips for individuals thinking of setting up a CRO.

Automation

Interview with Rob Durham (Gyros) on automation of assays and the Gyros Immunoassay

HT-ADME in a contract research organization laboratory: can you ensure bioanalytical quality in a highly automated environment?

Current advances and strategies towards fully automated sample preparation for regulated LC–MS/MS bioanalysis

Chromatography

Chiral HPLC column selection and method development guide (Sigma Aldrich)

High-throughput bioanalytical workflow for metabolic profiling of biological samples (Agilent)

Maternal and neonatal hair and breast milk in the assessment of perinatal exposure to drugs of abuse

Clinical

New method to evaluate drug resistant hepatitis C virus mutation

Test could anticipate a patient’s response to arthritis drugs

Add-on device for smartphone could one day detect pregnancy

Collaborations and Mergers

Press release: Quintiles and Quest Diagnostics Launch Q² Solutions

Press release: Randox invests £15 million in R&D ‘Roadmap’ to target the international personalized medicine market

Press release: Thermo Fisher Scientific proteomics facility for disease target discovery opens at Gladstone Institutes

Data Processing / Interpretation

Optimizing artificial neural network models for metabolomics and systems biology: an example using HPLC retention index data

Antibody-drug conjugate survey infographic

How to improve your peptide quantitation workflow to provide greater speed and reproducibility

Drug Discovery and Development

Biosimilar and Antibody Therapeutics Webinar Series

Starting a CRO on personal credit

Press release: Randox invests £15 million in R&D ‘Roadmap’ to target the international personalized medicine market

Forensic

Technique may allow forensic scientists to distinguish between identical twins’ DNA

New forensic technique is capable of identifying hair dye

What is the potential of measuring the enantiomeric ratio of drugs using supercritical fluid chromatography–MS?

Imaging

In situ drug and metabolite analysis in biological and clinical research by MALDI MS imaging

Advances in tissue section preparation for MALDI imaging MS

Screening method developed to detect prostate cancer recurrence

Ligand-binding

Considerations when developing ligand binding assays to support ADC programs

When close is not close enough: a comparison of endogenous and recombinant biomarker stability samples

Biosimilar and Antibody Therapeutics Webinar Series

Mass Spectrometry

High-throughput bioanalytical workflow for metabolic profiling of biological samples (Agilent)

Maternal and neonatal hair and breast milk in the assessment of perinatal exposure to drugs of abuse

The simultaneous detection and quantification of p-aminobenzoic acid and its phase 2 biotransformation metabolites in human urine using LC–MS/MS

Other

Graphene used to improve infrared absorption spectroscopy

New method to evaluate drug resistant hepatitis C virus mutation

Starting a CRO on personal credit

Regulated Bioanalysis

When close is not close enough: a comparison of endogenous and recombinant biomarker stability samples

Biosimilar and Antibody Therapeutics Webinar Series

Stability assessment in ligand-binding assays: a critical parameter for data integrity

Sample preparation, extraction & collection

Interview with Rob Durham (Gyros) on automation of assays and the Gyros Immunoassay

Testing underway for point-of-care device

Webinar Q&A transcription and follow-up: 'Transforming sample preparation'

Sports Drug Testing

What is the potential of measuring the enantiomeric ratio of drugs using supercritical fluid chromatography–MS?

Evaluation of horse urine sample preparation methods for metabolomics using LC coupled to HRMS

Affinity-based biosensors in sport medicine and doping control analysis

Toxicology

MALDI-MS offers new approach to cellular toxicity assays

Call for papers: Dried blood spots special focus issue

Trends in drug testing in oral fluid and hair as alternative matrices