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Automation

High-throughput mass spectrometric analysis of covalent protein-inhibitor adducts for the discovery of irreversible inhibitors: a complete workflow

Interview with Rob Durham (Gyros) on automation of assays and the Gyros Immunoassay

HT-ADME in a contract research organization laboratory: can you ensure bioanalytical quality in a highly automated environment?

Chromatography

LC-MS survey infographic

Development of a sensitive and fast UHPLC–MS/MS method for determination of clopidogrel, clopidogrel acid and clopidogrel active metabolite H4 in human plasma

Validation of an ultrasensitive LC–MS/MS method for PTH 1–34 in porcine plasma to support a solid dose PK study

Clinical

AAPS Crystal City VI Workshop: Bioanalytical Methods Validation on Biomarkers

Commentary on bioanalysis of ADCs survey results

Biotransformation and stability of antibody–drug conjugates: payload metabolism and linker cleavage delineation

Collaborations and Mergers

Press release: Quintiles and Quest Diagnostics Launch Q² Solutions

Press release: Randox invests £15 million in R&D ‘Roadmap’ to target the international personalized medicine market

Press release: Thermo Fisher Scientific proteomics facility for disease target discovery opens at Gladstone Institutes

Data Processing / Interpretation

Optimizing artificial neural network models for metabolomics and systems biology: an example using HPLC retention index data

Antibody-drug conjugate survey infographic

How to improve your peptide quantitation workflow to provide greater speed and reproducibility

Drug Discovery and Development

A new phase of drug discovery? The rise of PK/PD means extremely challenging work at the coalface

Systems for multiplexing homogeneous immunoassays

Interview with Walter Marlowe (American Association of Pharmaceutical Scientists (AAPS)) on the association's updated strategic plan

Forensic

Method developed to uncover the age of a fingerprint

Technique may allow forensic scientists to distinguish between identical twins’ DNA

New forensic technique is capable of identifying hair dye

Imaging

Firefly enzyme used for protein detection

In situ drug and metabolite analysis in biological and clinical research by MALDI MS imaging

Advances in tissue section preparation for MALDI imaging MS

Ligand-binding

Bioanalytical & Formulation Congress 15-16th September, Maritim proArte Hotel Berlin

What will be the topic for our next Spotlight? You decide!

New smartphone-based ELISA plate reader developed

Mass Spectrometry

Biomarker in breath could be used for early diagnosis of liver disease

LC-MS survey infographic

Method developed to uncover the age of a fingerprint

Other

How to set up a successful CRO by surrounding yourself with the right team members

Interview with Walter Marlowe (American Association of Pharmaceutical Scientists (AAPS)) on the association's updated strategic plan

Microfluidic device could significantly reduce diagnosis time for urinary tract infections

Regulated Bioanalysis

AAPS Crystal City VI Workshop: Bioanalytical Methods Validation on Biomarkers

Bioanalytical & Formulation Congress 15-16th September, Maritim proArte Hotel Berlin

When close is not close enough: a comparison of endogenous and recombinant biomarker stability samples

Sample preparation, extraction & collection

Development of a sensitive and fast UHPLC–MS/MS method for determination of clopidogrel, clopidogrel acid and clopidogrel active metabolite H4 in human plasma

Webinar Q&A follow up: 'A hybrid LBA/LC-MS assay: realize the best of both worlds'

High-throughput mass spectrometric analysis of covalent protein-inhibitor adducts for the discovery of irreversible inhibitors: a complete workflow

Sports Drug Testing

Seven new metabolites of anabolic steroid identified

What is the potential of measuring the enantiomeric ratio of drugs using supercritical fluid chromatography–MS?

Evaluation of horse urine sample preparation methods for metabolomics using LC coupled to HRMS

Toxicology

MALDI-MS offers new approach to cellular toxicity assays

Call for papers: Dried blood spots special focus issue

Trends in drug testing in oral fluid and hair as alternative matrices