In the Zone
In this series, we focus on some of the ‘hot topics’ in bioanalysis. Explore the topics we have covered so far with our insightful videos, infographics, editorials and expert podcasts, as well as journal articles from Bioanalysis made available to Bioanalysis Zone members. Topics coming soon include: COVID-19 vaccine assay development, flow cytometry, HRMS and virtual audits and software.
In the Zone: the COVID-19 vaccine effort
In this feature we focus on the COVID-19 vaccine effort and explore how do we decide that a vaccine is effective? Within this feature, we will show the various steps within the ...
Read moreIn the Zone: biomarker assays
Reliable diagnostic, prognostic, predictive, pharmacodynamic and pharmacokinetic biomarkers are critical to assure correct patient selection, drug dosing and monitoring. Being able to ...
Read moreIn the Zone: data management
Data management is a common terminology used in almost all industries. It comprises all disciplines related to managing data as a valuable resource. Regulated bioanalytical laboratories ...
Read moreIn the Zone: the use of singlicate analysis in LBAs
Ligand-binding assays (LBAs) including plate-based enzyme-linked immunosorbent assays (ELISAs) are a mainstay of the bioanalytical quantitation of biotherapeutic drugs in ...
Read moreIn the Zone: coronavirus
With coronavirus disease 2019 (COVID-19) shutting down countries and economies, the world is expectantly looking at scientist to come up with a solution. Although the novel severe acute ...
Read moreIn the Zone: ChipCytometry
To develop a thorough understanding of the biological problems that face the bioanalytical field today, we need to measure and visualize increasingly complex biochemical and ...
Read moreIn the Zone: HRMS versus QqQ
Traditionally, triple quadrupole mass spectrometry (QqQ) is viewed as the workhorse of the bioanalytical laboratory. However, developments in high-resolution mass spectrometry (HRMS) ...
Read moreIn the Zone: gene therapy – the era of AAV
Thousands of people are born with diseases caused by genetic defects every year. A gene mutation can result in the absence or reduced function of a critical protein. Less than 10% of ...
Read moreIn the Zone: immunogenicity
Pathogen immunity has long been determined by antibody-detection assays, however, in many situations, measuring T-cell immunity to specific pathogens can provide physicians with ...
Read moreIn the Zone: The bioanalyst – challenges and solutions
Assay development enables a drug or biochemical to be tested or measured. When analyzing a peptide of interest, it is important to choose and develop assays that are specific, sensitive ...
Read moreIn the Zone: Peptide Bioanalysis Sample Preparation
Bioanalysis is a critical part of the discovery and development of peptide therapeutics. LC–MS is an established technique for quantifying peptides; however, analysis of target analytes ...
Read moreIn the Zone: antibody-drug conjugates
Bioanalytical strategies for PK analysis of antibody–drug conjugate therapeutics using LC–HRMS & LC–MS/MS Antibody–drug conjugates (ADCs) combine the best of two modalities: toxin ...
Read moreIn the Zone: CAR-T cells
Chimeric antigen receptor T-cell therapy, known as CAR-T cell therapy, is an immunotherapy treatment option for cancer, whereby a patient’s T-cells are purified and manipulated in the ...
Read moreIn the Zone: alternative matrices
Whole blood, plasma, serum and urine samples are often utilized as key matrices for bioanalytical research, but what happens when these samples are inappropriate or unattainable for a ...
Read moreIn the Zone: flow cytometry
Flow cytometry is a versatile tool used for analyzing parameters on an individual cell basis. The technology measures fluorescence associated with cells, using refracted or emitted ...
Read moreIn the Zone: drug metabolism
Studying drug metabolism is vital in understanding the time course of a drug, critical dosages, toxicology of drug metabolites and other interactions of drug combinations. The rate a ...
Read moreIn the Zone: biotransformation
The biotransformation process plays a significant role in determining the fate of prospective drugs. The way that compounds are transformed from one form to another has a big impact on ...
Read moreIn the Zone: old vs new technologies
Investing in new technologies in the field of bioanalysis has its obvious advantages. New technologies often offer improved data quality and accuracy; better efficiency cutting costs ...
Read moreIn the Zone: immuno-oncology
Immuno-oncology is an evolving approach that harnesses a patient’s own immune system to help treat cancer. This treatment modality has great potential to enable the specific destruction ...
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