In the Zone

In this series, we focus on some of the ‘hot topics’ in bioanalysis. Explore the topics we have covered so far with our insightful videos, infographics, editorials and expert podcasts, as well as journal articles from Bioanalysis made available to Bioanalysis Zone members. Topics coming soon include: COVID-19 vaccine assay development, flow cytometry, HRMS and virtual audits and software.

In the Zone: phosphorylated biomarkers

An integral part of the drug development process is the proper identification of drug action and mechanism. One method to understand the pharmacodynamic effects of a drug on specific ...

In the Zone: virtual audits

As research continues throughout the COVID-19 pandemic, the need to continue operations as usual while maintaining regulatory compliance, presents unprecedented challenges for the ...

COVID-19 blood biomarkers for screening and treatment

In the Zone: the COVID-19 vaccine effort

In this feature we focus on the COVID-19 vaccine effort and explore how do we decide that a vaccine is effective? Within this feature, we will show the various steps within the ...

In the Zone: biomarker assays

Reliable diagnostic, prognostic, predictive, pharmacodynamic and pharmacokinetic biomarkers are critical to assure correct patient selection, drug dosing and monitoring. Being able to ...

In the Zone: data management

Data management is a common terminology used in almost all industries. It comprises all disciplines related to managing data as a valuable resource. Regulated bioanalytical laboratories ...

In the Zone: the use of singlicate analysis in LBAs

Ligand-binding assays (LBAs) including plate-based enzyme-linked immunosorbent assays (ELISAs) are a mainstay of the bioanalytical quantitation of biotherapeutic drugs in ...

In the Zone: coronavirus

With coronavirus disease 2019 (COVID-19) shutting down countries and economies, the world is expectantly looking at scientist to come up with a solution. Although the novel severe acute ...

In the Zone: ChipCytometry

To develop a thorough understanding of the biological problems that face the bioanalytical field today, we need to measure and visualize increasingly complex biochemical and ...

In the Zone: HRMS versus QqQ

Traditionally, triple quadrupole mass spectrometry (QqQ) is viewed as the workhorse of the bioanalytical laboratory. However, developments in high-resolution mass spectrometry (HRMS) ...

In the Zone: gene therapy – the era of AAV

Thousands of people are born with diseases caused by genetic defects every year. A gene mutation can result in the absence or reduced function of a critical protein. Less than 10% of ...

In the Zone: immunogenicity

Pathogen immunity has long been determined by antibody-detection assays, however, in many situations, measuring T-cell immunity to specific pathogens can provide physicians with ...

In the Zone: The bioanalyst – challenges and solutions

Assay development enables a drug or biochemical to be tested or measured. When analyzing a peptide of interest, it is important to choose and develop assays that are specific, sensitive ...

In the Zone: Peptide Bioanalysis Sample Preparation

Bioanalysis is a critical part of the discovery and development of peptide therapeutics. LC–MS is an established technique for quantifying peptides; however, analysis of target analytes ...

In the Zone: antibody-drug conjugates

Bioanalytical strategies for PK analysis of antibody–drug conjugate therapeutics using LC–HRMS & LC–MS/MS Antibody–drug conjugates (ADCs) combine the best of two modalities: toxin ...

In the Zone: CAR-T cells

Chimeric antigen receptor T-cell therapy, known as CAR-T cell therapy, is an immunotherapy treatment option for cancer, whereby a patient’s T-cells are purified and manipulated in the ...

In the Zone: alternative matrices

Whole blood, plasma, serum and urine samples are often utilized as key matrices for bioanalytical research, but what happens when these samples are inappropriate or unattainable for a ...

In the Zone: flow cytometry

Flow cytometry is a versatile tool used for analyzing parameters on an individual cell basis. The technology measures fluorescence associated with cells, using refracted or emitted ...

In the Zone: drug metabolism

Studying drug metabolism is vital in understanding the time course of a drug, critical dosages, toxicology of drug metabolites and other interactions of drug combinations. The rate a ...

In the Zone: biotransformation

The biotransformation process plays a significant role in determining the fate of prospective drugs. The way that compounds are transformed from one form to another has a big impact on ...

In the Zone: old vs new technologies

Investing in new technologies in the field of bioanalysis has its obvious advantages. New technologies often offer improved data quality and accuracy; better efficiency cutting costs ...

In the Zone: immuno-oncology

Immuno-oncology is an evolving approach that harnesses a patient’s own immune system to help treat cancer. This treatment modality has great potential to enable the specific destruction ...