In the Zone: phosphorylated biomarkers

An integral part of the drug development process is the proper identification of drug action and mechanism. One method to understand the pharmacodynamic effects of a drug on specific ...

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In the Zone: virtual audits

As research continues throughout the COVID-19 pandemic, the need to continue operations as usual while maintaining regulatory compliance, presents unprecedented challenges for the ...

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In the Zone: the COVID-19 vaccine effort

  In this feature we focus on the COVID-19 vaccine effort and explore how do we decide that a vaccine is effective? Within this feature, we will show the various steps within the ...

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In the Zone: biomarker assays

Reliable diagnostic, prognostic, predictive, pharmacodynamic and pharmacokinetic biomarkers are critical to assure correct patient selection, drug dosing and monitoring. Being able to ...

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In the Zone: data management

Data management is a common terminology used in almost all industries. It comprises all disciplines related to managing data as a valuable resource. Regulated bioanalytical laboratories ...

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In the Zone: the use of singlicate analysis in LBAs

Ligand-binding assays (LBAs) including plate-based enzyme-linked immunosorbent assays (ELISAs) are a mainstay of the bioanalytical quantitation of biotherapeutic drugs in ...

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In the Zone: coronavirus

With coronavirus disease 2019 (COVID-19) shutting down countries and economies, the world is expectantly looking at scientist to come up with a solution. Although the novel severe acute ...

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In the Zone: ChipCytometry

To develop a thorough understanding of the biological problems that face the bioanalytical field today, we need to measure and visualize increasingly complex biochemical and ...

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In the Zone: HRMS versus QqQ

Traditionally, triple quadrupole mass spectrometry (QqQ) is viewed as the workhorse of the bioanalytical laboratory. However, developments in high-resolution mass spectrometry (HRMS) ...

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In the Zone: gene therapy – the era of AAV

Thousands of people are born with diseases caused by genetic defects every year. A gene mutation can result in the absence or reduced function of a critical protein. Less than 10% of ...

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In the Zone: immunogenicity

Pathogen immunity has long been determined by antibody-detection assays, however, in many situations, measuring T-cell immunity to specific pathogens can provide physicians with ...

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In the Zone: The bioanalyst – challenges and solutions

Assay development enables a drug or biochemical to be tested or measured. When analyzing a peptide of interest, it is important to choose and develop assays that are specific, sensitive ...

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In the Zone: Peptide Bioanalysis Sample Preparation

Bioanalysis is a critical part of the discovery and development of peptide therapeutics. LC–MS is an established technique for quantifying peptides; however, analysis of target analytes ...

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In the Zone: antibody-drug conjugates

Bioanalytical strategies for PK analysis of antibody–drug conjugate therapeutics using LC–HRMS & LC–MS/MS Antibody–drug conjugates (ADCs) combine the best of two modalities: toxin ...

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In the Zone: CAR-T cells

Chimeric antigen receptor T-cell therapy, known as CAR-T cell therapy, is an immunotherapy treatment option for cancer, whereby a patient’s T-cells are purified and manipulated in the ...

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In the Zone: alternative matrices

Whole blood, plasma, serum and urine samples are often utilized as key matrices for bioanalytical research, but what happens when these samples are inappropriate or unattainable for a ...

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In the Zone: flow cytometry

Flow cytometry is a versatile tool used for analyzing parameters on an individual cell basis. The technology measures fluorescence associated with cells, using refracted or emitted ...

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In the Zone: drug metabolism

Studying drug metabolism is vital in understanding the time course of a drug, critical dosages, toxicology of drug metabolites and other interactions of drug combinations. The rate a ...

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In the Zone: biotransformation

The biotransformation process plays a significant role in determining the fate of prospective drugs. The way that compounds are transformed from one form to another has a big impact on ...

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In the Zone: old vs new technologies

Investing in new technologies in the field of bioanalysis has its obvious advantages. New technologies often offer improved data quality and accuracy; better efficiency cutting costs ...

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In the Zone: immuno-oncology

Immuno-oncology is an evolving approach that harnesses a patient’s own immune system to help treat cancer. This treatment modality has great potential to enable the specific destruction ...

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