In the Zone: alternative matrices

Whole blood, plasma, serum and urine samples are often utilized as key matrices for bioanalytical research, but what happens when these samples are inappropriate or unattainable for a particular study? What happens when the analysis costs are too high or a better option for sample preparation is available?

In toxicological analyses, researchers have found alternative matrices such as saliva, sweat and hair to be adequate and accurate indicators for the detection of illicit or potentially harmful compounds. The benefits of utilizing minimally invasive strategies for sample collection include the advantage of increased frequency of sample collection, as well as increased opportunities for convenient and stress-free self-sampling for the patient.

In this feature, we will be investigating different alternative matrices that are available to the bioanalytical scientist and what questions need to be asked when deciding on the appropriate matrix to answer specific bioanalytical questions.

We will also be talking to our experts about the future of alternative matrices and discussing the key challenges that will need to be overcome in order to progress sample preparation and detection.



The future of alternative matrices in bioanalytical workflows: an interview with Amy Mize (KCAS Bioanalytical & Biomarker Services)

In this exclusive interview, Amy Mize (KCAS Bioanalytical & Biomarker Services; KS, USA) describes how alternative matrices can be applied to bioanalytical studies and what challenges need to be addressed in order to further the use of alternative matrices in regulated bioanalytical workflows in the future.





Top 5 tips for utilizing alternative matrices


Find out more about how to adopt alternative matrices into your workflow in this informative infographic from KCAS Bioanalytical Services. Learn more about refining your study design, working with regulatory guidelines and collaborating with other scientists in these five top tips.





Bioanalysis Zone hexagon1 Spotting of external calibration standards on blank dried blood spots as a resource-sparing protocol

2 Parallel Artificial Liquid Membrane Extraction of Psychoactive Analytes-a novel approach in therapeutic drug monitoring

3 Microsampling in sports drug testing – an interview with Laura Mercolini (University of Bologna)



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