LATEST WEBINARS
Live date: Thursday 13 February 2020 15:00 [GMT] 10:00 [EST] 07:00 [PST]. Register for our exclusive Coffee Chat focusing on developments in cell and gene therapies. This informal discussion centers around gene therapy medicinal products and their potential to change the way we fight disease.
Available on demand. LC–MS based large molecule bioanalysis platform was developed, validated and applied for drug screening and preclinical pharmacokinetics.
Available on demand. The demonstration of similar immunogenicity is a critical requirement for the demonstration of similarity between a biosimilar candidate and the respective reference product.
Webinar now available on demand. The aim of DMPK is to enable scientists to learn the safety and efficacy of new molecular entities. HRMS is an important analytical tool used to study DMPK that continues to gain traction when quantifying molecules.
Webinar now available on demand. Absolute quantitation of intact biotherapeutics is enabled through advances in immunocapture techniques coupled to LC–MS.
Webinar live date: Thursday 12 December 2019 07:00 [PST] 10:00 [EST] 15:00 [GMT]. On December 12, join us as we discuss, with supporting case studies, how hybridization ELISA can be an effective approach to quantify antisense oligonucleotides in circulation and in their targeted tissue.
Panel discussion available on demand. In this free panel discussion, our experts will provide insights into their own research using oligonucleotides, including the most common challenges encountered, key trends they have seen as the field develops and their opinions on the future outlook of the technology.
Webinar now available on demand. Learn about the sensitivity gains afforded by microflow chromatography vs high-flow and what potential this has for Met ID. See how this translates to stronger spectra in turn resulting in more metabolites being identified and characterized.
Thank you everyone who attended our live webinar ‘Exploratory biomarker testing: to qualify or validate the assay? The latest scientific and regulatory considerations for biomarker validation‘ in association with BioAgilytix.
Webinar available on demand. A ‘tips and tricks’ approach to understanding and optimizing chromatography of oligonucleotides. Taking into consideration the nature of the oligonucleotide you are interested in, you will be able to make informed choices about what approach to use.
Webinar available on demand. An overview of Gyrolab immunoassays and their utility in CMC target binding assays for batch release and stability assessment. Also, for preclinical and clinical PK analysis with a view to transferring assays to a CRO.
Webinar available on demand. In this free panel discussion, our experts will provide insights into their own research using ligand binding assays including the challenges they have had to overcome, key trends they have seen and their future outlook on the development of this field.
Latest News
Researchers are presenting the details of a new blood-based assay that utilizes cell-free DNA to identify the methylation signals of gastrointestinal cancers at the Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 23–25 January 2020.
Thermo Fisher Scientific (MA, USA) have released the Thermo Scientific NanoDrop QC software. The software could simplify sample quality control for industrial users and could help to save time during sample preparation.
Researchers from Brigham and Women’s Hospital (MA, USA) report a new quantitative technique, based on measuring the fraction of T cells in a tumor sample, that could be used to predict the risk of melanoma recurrence.
Latest Features
To coincide with Chinese New Year, Bioanalysis Zone are exploring China’s engaging bioanalytical community and examining the exciting bioanalytical work and developments taking place in the bioanalytical landscape of China.
In this instalment of Robert Macneill’s (Covance) column, Robert explores the potential information to be gleaned from calibration curves and how these insights could possibly fuel innovation in the field of biomarker quantification.
Author Montserrat Carrasco-Triguero (Genentech, CA, USA) gives us an insight into her research career and her paper published in Bioanalysis: Immunogenicity of antibody–drug conjugates: observations across 8 molecules in 11 clinical trials, in this author’s perspective feature.
Drug Discovery and Development
Winner of the 2019 BOSCA announced!
Drug detection in biological specimens: recent colorimetric methods
Signal amplification technology reveals previously undetectable proteins of disease
Ligand-binding
Perspectives on exploring hybrid LBA/LC–MS approach for clinical immunogenicity testing
Biotherapeutic characterization and quantification: an interview with Pegah Jalili
Mass Spectrometry
Winner of the 2019 BOSCA announced!
Optimization of microflow LC–MS/MS and its utility in quantitative discovery bioanalysis
Perspectives on exploring hybrid LBA/LC–MS approach for clinical immunogenicity testing
Sample preparation, extraction & collection
Digitalization in medicine: mobile-based assay for determination of inflammation?
Key challenges in sample preparation for peptide bioanalysis: a podcast with Mary Lame
Identifying critical quality attributes using Agilent AdvanceBio Columns