LATEST WEBINARS
Webinar live date: Wednesday 3 October 2019 07:00 [PDT] 10:00 [EDT] 15:00 [BST]. An overview of Gyrolab immunoassays and their utility in CMC target binding assays for batch release and stability assessment. Also, for preclinical and clinical PK analysis with a view to transferring assays to a CRO.
Panel discussion live date: Thursday 19 September 2019 07:00 [PDT] 10:00 [EDT] 15:00 [BST]. In this free panel discussion, our experts will provide insights into their own research using ligand binding assays including the challenges they have had to overcome, key trends they have seen and their future outlook on the development of this field.
Webinar available on demand. This webinar will discuss considerations for biomarker assay design and technology selection, including singleplex and multiplex ligand binding and immunometric assays, as well as optimization of pre-analytical factors and core assay performance expectations.
Webinar live date: 10 September 2019 07:00 [PDT] 10:00 [EDT] 15:00 [BST]. Join us for a discussion on proactive, effective and efficient bioanalytical project management.
Webinar available to view on demand. Learn about the most advanced methods for quantitating and characterizing therapeutic oligonucleotides.
Webinar available to view on demand. Register for our exclusive panel discussion focusing on the new ICH M10 guideline on bioanalytical method validation.
Webinar available to view on demand. Join us for a discussion on how bioanalytical data is used in early-phase clinical trials to advance drug development.
Webinar available to view on demand. Learn how using serial immunoaffinity (IA) enrichment and targeted MS offers the possibility to measure multiple protein targets with great sensitivity from a single sample.
Panel discussion available to view on demand. In this free panel discussion, our experts will provide insights into their own research using flow cytometry including the challenges they have had to overcome, key trends they have seen and their future outlook on the development of this field.
Latest News
An early pilot study has shown that special analysis of the lens of the eye by a newly developed biomicroscope could be able to predict Type 2 diabetes.
A novel interferometric technique could breathe new life into the use of single-molecule localization microscopy in biomacromolecule research.
A recent study reports a new biomarker panel, comprised of 28 physical and molecule measures, that could successfully confirm the diagnosis of warzone-related post-traumatic stress disorder (PTSD) with 77% accuracy.
Latest Features
This infographic reflects changes in the oligonucleotide field over the last 2 years including: what types of oligonucleotides are studied, assay formats and opinions on methodology for oligonucleotide analysis.
Although qPCR is a golden standard for sensitive quantitation of DNA and mRNA molecules, the assays usually have insufficient sensitivity for short or heavily modified oligonucleotide therapeutics. In this editorial, the authors discuss the development of oligonucleotide-based therapeutics and the methods used to study them.
In this editorial, Neil Henderson (AstraZeneca) discusses the explosion in types of drug molecules – the so-called ‘new modality’ drugs – which includes antisense oligonucleotides (ASOs) and modified mRNA.
Drug Discovery and Development
Drug detection in biological specimens: recent colorimetric methods
Signal amplification technology reveals previously undetectable proteins of disease
Bioanalytical laboratory considerations for immuno-oncology drug development
Ligand-binding
Perspectives on exploring hybrid LBA/LC–MS approach for clinical immunogenicity testing
Biotherapeutic characterization and quantification: an interview with Pegah Jalili
Mass Spectrometry
Optimization of microflow LC–MS/MS and its utility in quantitative discovery bioanalysis
Perspectives on exploring hybrid LBA/LC–MS approach for clinical immunogenicity testing
LC–HRMS quantitation of intact antibody drug conjugate trastuzumab emtansine from rat plasma
Sample preparation, extraction & collection
Key challenges in sample preparation for peptide bioanalysis: a podcast with Mary Lame
Identifying critical quality attributes using Agilent AdvanceBio Columns