Spotlights

0 Large molecule quantification by LC–MS

In order to explore the most recent developments in large molecule quantification in regulated bioanalysis by LC–MS, this Spotlight will highlight the advances and challenges faced during method development, validation and samples analysis.

0 Oligonucleotides

In this Spotlight we will be exploring the recent developments and the unique challenges that oligonucleotides bring to the bioanalytical community.

0 Quantitative HRMS

Welcome to the Bioanalysis Zone Spotlight on Quantitative HRMS! HRMS has been available for a long time; originally it was…

0 Hybrid LBA/LC-MS

Welcome to the Bioanalysis Zone Spotlight on Hybrid LBA/LC-MS! LBA is historically the gold standard for biologics and is employed…

0 LC-MS

Welcome to the Bioanalysis Zone Spotlight on LC-MS! LC-MS is used in the pharmaceutical industry to provide quantitative measurements of…

0 Antibody–drug conjugates

Welcome to the Bioanalysis Zone Spotlight on antibody-drug conjugates (ADCs)! ADCs are dynamic, heterogeneous mixtures typically consisting of a cytotoxic…

0 Automation

Automation can increase throughput while maintaining quality; this increase in efficiency can lead to a reduction in the cost of…

0 Metabolomics

Welcome to the Bioanalysis Zone Spotlight on Metabolomics! In recent years, metabolomics has become a ‘hot topic’ in bioanalysis; the…

0 Microsampling: the road ahead

Welcome to the Bioanalysis Zone Spotlight on Microsampling: the road ahead!

There has been continued interest in microsampling both in the literature and at scientific meetings in recent years, driven by factors including:

– Implications for 3Rs (replacement, reduction, refinement) in animal studies
– Maximizing information from animal pharmacology models in small animals
– Logistical benefits for clinical

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