Welcome to the Bioanalysis Zone Spotlight on Quantitative HRMS!
HRMS has been available for a long time; originally it was applied in qualitative applications, however the introduction of spectrometers with improved mass resolution over wider mass ranges has allowed for the application of HRMS in quantitative workflows.
In the clinical setting, HRMS is increasingly being adopted due to its ease of operation, reasonable cost and maintenance. HRMS can also be combined with qualitative exploration of data in the small-molecule field.
In this Spotlight we will cover the advantages of HRMS and the remaining hurdles, such as; does the combination of qualitative and quantitative workflows result in less efficient bioanalytical assays?