LC–MS in early discovery-stage workflows
LC–MS is a versatile method used to separate compounds based on their weight and affinity for the mobile and stationary phases of the column. Proteins and complex peptides, which are large and non-volatile, can be easily separated by LC–MS and different column chemistries can be used such as reversed phase liquid chromatography.
The use of LC–MS in early discovery stage-workflows enables rapid screening of large compound libraries for activity against biological targets. This technique can accelerate the early drug screening process, identifying compounds with potential – known as drug leads – and reduce time spent on discovering inefficient leads.
As part of this Spotlight, we will explore:
- LC–MS technologies used to accelerate drug discovery
- Different instrumentation
- Emerging industry trends