LC–MS in early discovery-stage workflows

LC–MS is a versatile method used to separate compounds based on their weight and affinity for the mobile and stationary phases of the column. Proteins and complex peptides, which are large and non-volatile, can be easily separated by LC–MS and different column chemistries can be used such as reversed phase liquid chromatography.  

The use of LC–MS in early discovery stage-workflows enables rapid screening of large compound libraries for activity against biological targets. This technique can accelerate the early drug screening process, identifying compounds with potential – known as drug leads – and reduce time spent on discovering inefficient leads. 

As part of this Spotlight, we will explore: 

  • LC–MS technologies used to accelerate drug discovery 
  • Different instrumentation 
  • Emerging industry trends

This feature was produced in association with SCIEX and Covance

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