Using phosphoproteomics to monitor disregulated signaling networks in cardiac disease preceding heart failure

“The phosphoproteomic field has reached a sufficiently high technical level that, with constant improvements to analytical proficiency, it is ready to be applied to a variety of topics in cardiovascular research.” Cardiovascular diseases (CVDs) leading to heart failure (HF) are now the leading causes of mortality in North America. Indeed, global healthcare systems are faced with the growing burden of a rapidly increasing incidence of chronic CVD/HF [1]. Since patients are typically diagnosed with irreversible late end-stage disease once they display symptoms, dramatic improvements are needed in the treatment of the initial acute stages of heart disease. However, the etiology...