Bioanalysis Zone

Evaluation of matrix effect when matrix factor is not enough for LC-MS/MS bioanalytical method (inVentiv Health Clinical)



Matrix effect must be evaluated for LC-MS/MS bioanalytical methods. EMA suggests to evaluate the matrix effect with the matrix factor procedure. Herein, two procedures are described using pyridoxine-5-phosphate (Pn5P) showing that matrix effect cannot be associated exclusively to ionic suppression or enhancement.

View the poster by clicking here.

To get a PDF version of this poster please click here.


Leave A Comment