Non-capillary microsampling of plasma in rat and mice in support of GLP studies

Hans Stieltjes (Janssen Research & Development) has kindly provided Bioanalysis Zone a preview of his team's novel research on non-capillary microsampling of plasma in rat and mice in support of GLP studies. Please note this work is pending peer-review. Background: Different liquid microsampling techniques to obtain plasma samples have created great interest from toxicokinetic and pharmacokinetic scientists [1, 2]. These techniques enable reduction of sample volumes for exposure assessment in rodents and, consequently, serial profiles can be obtained from a single animal. In GLP safety studies, microsampling can remove the use of satellite animals. Although the full potential to reduce...