Bioanalysis Zone

ICP–MS determination of serum aluminum in monkeys subcutaneously administered an alhydrogel-formulated drug candidate

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Aim: To develop and validate an inductively coupled plasma–mass spectrometry method for quantitative bioanalysis of aluminum (Al) in monkey serum in support of a GLP TOX study with alhydrogel-formulated drug candidate. Methods & results: The method was linear over a dynamic range of 10–1000 ng/ml using a 50-μl sample volume. The intra-/inter-run precision (%CV) of the quality control sample results were

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