Bioanalysis Zone

Extended 3D and 4D cumulative plots for evaluation of unmatched incurred sample reanalysis


Aim: Incurred sample reanalysis (ISR) helps ensure the reliability of pharmacokinetic studies. An appropriate graph may facilitate the evaluation of an unmatched reanalyses or a failed ISR test.

Methods: We evaluated different ways of visualizing multidimensional ISR data using an extended cumulative ISR plot.

Results: 3D and 4D cumulative ISR plots enable

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Hear from the author, Piotr Rudzki, about this research in an exclusive author’s perspective interview, here.


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