In this research article from Bioanalysis, the authors quantified and identifed over 50 analytes from human biological matrices by HPLC, NMR and LC–MS to obtain structural information on phenolic acid metabolites.
Alternative scaffold proteins have emerged as novel platforms for development of therapeutic applications. One such application is in protein–drug conjugates, which are analogous to antibody–drug conjugates. Find out more in this research article from Bioanalysis.
In this research article from Future Science OA, the authors investigate antibiotic resistance in Escherichia coli, which causes most urinary tract infections, by quantifying ampicillin in real-time using a combined LC–MS/MS and hollow-fiber infection model.
A noninvasive skin-stripping test has been developed to differentiate between eczema and psoriasis when diagnosing inflammatory skin diseases.
Find out more about the current views and recommendations from the European Bioanalysis Forum on incurred sample reanalysis in this article from Bioanalysis.
In this methodology article from Bioanalysis, H Li et al. describe the use of the Mitra® microsampler for blood sampling, ELISA quantitation and PK analysis of two marketed therapeutic monoclonal antibodies administered to rats.
Can bioanalysis be aimed without convergence of specificity and selectivity? Is it possible to converge both the strategies? Find out more in this article from Bioanalysis, where the authors discuss the merits and challenges of bioanalysis in terms of specificity versus selectivity in order to find the solutions.
In this manuscript, the European Bioanalysis Forum presents additional practice guidance on the use of flow cytometry in the support of drug development programs and addresses areas that are not covered in the previous publications.
We have developed a simple, cost-effective, and labor-efficient two-step protocol for preparing adherent cells for high-throughput flow cytometry. Adherent cells…
Flow cytometry is increasingly recognized as an invaluable technology in biomarker research. Owing to its multiparametric nature it can provide highly detailed information on any single cell in a heterogeneous population. Find out more in this review from Bioanalysis.