Part one of the White Paper published in Bioanalysis from the 2019 13th Workshop on Recent Issues in Bioanalysis (WRIB) covers the use of chromatographic assays in bioanalysis.
In this research article from Bioanalysis learn more about the immunogenicity of anti-body drug conjugates. The research follows eight molecules across 11 clinical trials to evaluate the potentially increased immunogenicity risk of these multi-domain biotherapeutics compared with monoclonal antibodies.
Learn about the development of a robust HPLC-MS/MS method to determine the concentration of everolimus in the eye aqeuous humor and the future outlook for further research in this research article from Bioanalysis.
In this perspective article from Bioanalysis the authors explore key considerations when selecting an IS and propose experiments to perform within the method development phase to demonstrate suitability of the IS within the assay prior to validation.
One of the most common issues introduced to primary care clinics is low back pain. Nonsteroidal anti-inflammatory drugs (NSAIDs) and…
Learn more about the positive impact of upfront systematic screening and characterization of conjugated critical reagent attributes on assay robustness in this methodology article in Bioanalysis.
Find out what regulatory recommendations exist for bioanalytical support of adeno-associated virus gene therapy development in this Bioanalysis article giving an overview of the current regulatory recommendations as found in FDA and EMA guidance documents.
Lipoic acid supplementation is known to have a prophylactic affect on many diet-realted diseases. This research article from Bioanalysis reports the first method to determine lipoyllysine levels in human urine following lipoic acid supplementation.
Learn more about the use of standard-flow ESI in quantitative proteomic studies and the identification of new NPC1 protein markers in this research article from Bioanalysis.
Learn more about the potential impact of a retention time table and a list of appropriate standards as a resource for targeted sphingolipidomics in this article in Bioanalysis.