This article from Bioanalysis is focused on the challenges in the development of flow cytometry bioanalytical methods to quantitatively measure CAR-T cell levels in adoptive cell therapy.
This review article from Bioanalysis> summarizes recent practices and considerations in bioanalytical support of pharmacokinetics and pharmacodynamics evaluations in gene therapy development with insight into method design, development and validations.
This part the 2018 White Paper published in Bioanalysis covers the recommendations for large molecule bioanalysis, biomarkers and immunogenicity using LBA and cell-based assays.
This review article from Bioanalysis> introduces the differences between UHPLC and HPLC, and reviews the use of UHPLC in the last 5 years when studying the glycosylation of proteins and glycoprofiling biopharmaceuticals.
In this research article from Bioanalysis, the authors quantified and identifed over 50 analytes from human biological matrices by HPLC, NMR and LC–MS to obtain structural information on phenolic acid metabolites.
Alternative scaffold proteins have emerged as novel platforms for development of therapeutic applications. One such application is in protein–drug conjugates, which are analogous to antibody–drug conjugates. Find out more in this research article from Bioanalysis.
In this research article from Future Science OA, the authors investigate antibiotic resistance in Escherichia coli, which causes most urinary tract infections, by quantifying ampicillin in real-time using a combined LC–MS/MS and hollow-fiber infection model.
A noninvasive skin-stripping test has been developed to differentiate between eczema and psoriasis when diagnosing inflammatory skin diseases.
Find out more about the current views and recommendations from the European Bioanalysis Forum on incurred sample reanalysis in this article from Bioanalysis.