This commentary from Bioanalysis focuses on the status of drug detection with metal nanoparticles as ultrasmall labels in colorimetric-based methods.
In this methodology from Bioanalysis, the authors investigate the detection of Ki67 – a prognostic and/or predictive biomarker in patients with malignancies – in human blood using flow cytometry for single-cell multiparameter analysis.
This part of the 2018 White Paper published in Bioanalysis focuses on the recommendations for PK, PD and ADA assays by hybrid LBA/LCMS and regulatory agencies’ input.
This part of the 2018 White Paper published in Bioanalysis discusses the recommendations for LC–MS for small molecules, peptides, oligonucleotides and small molecule biomarkers.
This article from Bioanalysis is focused on the challenges in the development of flow cytometry bioanalytical methods to quantitatively measure CAR-T cell levels in adoptive cell therapy.
This review article from Bioanalysis> summarizes recent practices and considerations in bioanalytical support of pharmacokinetics and pharmacodynamics evaluations in gene therapy development with insight into method design, development and validations.
This part of the 2018 White Paper published in Bioanalysis covers the recommendations for large molecule bioanalysis, biomarkers and immunogenicity using LBA and cell-based assays.
This review article from Bioanalysis> introduces the differences between UHPLC and HPLC, and reviews the use of UHPLC in the last 5 years when studying the glycosylation of proteins and glycoprofiling biopharmaceuticals.