In this article the authors discuss GMP testing for oligonucleotide drug substance and drug product.
In this interview, Shalini Prasad from the University of Texas at Dallas (TX, USA), discusses her current research in the development of a multiplex diagnostic wearable.
In this interview, we talk to Omnia Ismaiel on her latest article, ‘Do we have mature LC–MS/MS methodology for therapeutic monoclonal antibody bioanalysis?’.
In this Column, Stuart A. Kushon (Neoteryx; CA, USA) discusses what he feels is the key to successful implementation of microsampling.
Bioanalysis of Diagnostic and Therapeutic Oligonucleotides: An Emphasis on LC-FL and LC-MS Based Assays
In this article, recent developments and considerations for liquid chromatographic (LC) methods of oligonucleotides are discussed, highlighting LC-Mass Spectrometry and LC-Fluorescence assays, and the benefits of systematic incorporation into a bioanalysis laboratory.
In this article Johannes Winkler discusses how the recent clinical successes prove that synthetic oligonucleotides are useful therapeutic agents and outlines some obstacles that need to be overcome for a more widespread and safe application.
In this interview, Min Meng discusses the changing landscape of oligonucleotides in bioanalysis, including how the industry has changed over the last decade as well as the advantages and disadvantages of different analytical methods.
LGC (Teddington, UK) have announced the combination of their Biosearch oligonucleotide reagent group with the newly acquired LINK technology, in the hope of enhancing oligonucleotide capabilities.
Bioanalysis Zone are delighted to partner with The Chromatographic Society at the 22nd International Reid Bioanalytical Forum (4–7 September; Cambourne, UK). We have the pleasure of publishing exclusive content and presentations directly from Reid, including a live stream from the first talk, ‘Bioanalysis of the future’.
In this article, Eric Tewalt and James Gorman discuss updates and considerations for the utilization of hybridization ELISA methods, including associated benefits and challenges, for the bioanalysis of oligonucleotides.