Bioanalysis> commissioning Editor, Rhiannon Finnie, reflects on the journal’s highlights from 2018 including special focus issues and the most popular articles of the year.
Browsing: Journal Articles
This review article from Bioanalysis> introduces the differences between UHPLC and HPLC, and reviews the use of UHPLC in the last 5 years when studying the glycosylation of proteins and glycoprofiling biopharmaceuticals.
Quantification of phenolic acid metabolites in humans by LC–MS: a structural and targeted metabolomics approach
In this research article from Bioanalysis, the authors quantified and identifed over 50 analytes from human biological matrices by HPLC, NMR and LC–MS to obtain structural information on phenolic acid metabolites.
Bioanalytical workflow for novel scaffold protein–drug conjugates: quantitation of total Centyrin protein, conjugated Centyrin and free payload for Centyrin–drug conjugate in plasma and tissue samples using liquid chromatography–tandem mass spectrometry
Alternative scaffold proteins have emerged as novel platforms for development of therapeutic applications. One such application is in protein–drug conjugates, which are analogous to antibody–drug conjugates. Find out more in this research article from Bioanalysis.
Combining LC–MS/MS and hollow-fiber infection model for real-time quantitation of ampicillin to antimicrobial resistance
In this research article from Future Science OA, the authors investigate antibiotic resistance in Escherichia coli, which causes most urinary tract infections, by quantifying ampicillin in real-time using a combined LC–MS/MS and hollow-fiber infection model.
A noninvasive skin-stripping test has been developed to differentiate between eczema and psoriasis when diagnosing inflammatory skin diseases.
Incurred sample reproducibility: 10 years of experiences: views and recommendations from the European Bioanalysis Forum
Find out more about the current views and recommendations from the European Bioanalysis Forum on incurred sample reanalysis in this article from Bioanalysis.
Application of Mitra® Microsampling for Pharmacokinetic Bioanalysis of Monoclonal Antibodies in Rats
In this methodology article from Bioanalysis, H Li et al. describe the use of the Mitra® microsampler for blood sampling, ELISA quantitation and PK analysis of two marketed therapeutic monoclonal antibodies administered to rats.
Can bioanalysis be aimed without convergence of specificity and selectivity? Is it possible to converge both the strategies? Find out more in this article from Bioanalysis, where the authors discuss the merits and challenges of bioanalysis in terms of specificity versus selectivity in order to find the solutions.
Best practices in performing flow cytometry in a regulated environment: feedback from experience within the European Bioanalysis Forum
In this manuscript, the European Bioanalysis Forum presents additional practice guidance on the use of flow cytometry in the support of drug development programs and addresses areas that are not covered in the previous publications.