This editorial looks to highlight the major advantages of MS in the clinical laboratory, explain the major hurdles in place and provide an insight into the potential applications for clinical biomarker analysis.
Browsing: Journal Articles
Development of a UHPLC–MS/MS (SRM) method for the quantitation of endogenous glucagon and dosed GLP-1 from human plasma
In this research article, the authors discuss how the use of LC–MS/MS could offer a viable alternative to immunoassays for the quantitation of endogenous glucagon, dosed glucagon and/or dosed GLP-1.
The authors discuss a disposable diagnostic biosensor for detecting and quantifying levels of cardiac tropinin-T from human serum.
Feedback from the EBF – Focus Workshop: bringing assay validation and analysis of biomarkers into practice
This conference report, from the European Bioanalysis Forum Focus Workshop, Lisbon, Portugal, 9–10 June 2016, summarizes the essence from the conference discussions and from the proposals or conclusions made by all delegates on how to increase the necessary connectivity of the stakeholders involved in the bioanalysis of biomarkers.
In this commentary, the authors discuss test materials and study designs of method transfer studies for biotechnology products.
The following white paper outlines the critical aspects of biomarker specimen stability that are commonly encountered during clinical development
Validation of electrochemiluminescence assays for highly sensitive and reproducible quantification of α-synuclein in cerebrospinal fluid
In this research article, the authors outlime the development and validation of electrochemilumiescence assays for quantification of α-synuclein, a putative biomarker for the diagnosis of Parkinson’s disease and related disorders.
Plasma protein binding monitoring of therapeutic drugs in patients using single set of hollow fiber centrifugal ultrafiltration
In this study, a novel method was proposed to analyze free drug concentration and total drug concentration.
The 10th GCC Closed Forum: rejected data, GCP in bioanalysis, extract stability, BAV, processed batch acceptance, matrix stability, critical reagents, ELN and data integrity and counteracting fraud
In this conference report from the 10th Global CRO council closed forum, the authors discuss scientific and regulatory issues specific to CROs within bioanalysis.
In this Methodology, the authors outline their use of capillary microsampling to collect smaller volumes of blood samples and the eliminated toxicokinetic satellite groups, during GLP toxicology studies.