Browsing: Metabolites

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In this feature, we present a collection of resources focusing on the ‘hot topic’ of biotransformation, including: an introduction to what it is, a podcast discussing the technologies used to characterize biotransformation and an infographic with our top 5 challenges for the biotransformation scientist and software solutions.

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A collaboration of researchers from KAUST (Thuwal, Saudi Arabia), Imperial College London (London, UK) and the University of Cambridge (Cambridge, UK), have recently developed a novel concept for a biosensor of the metabolite, lactate.

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In this interview with Ragu Ramanathan (Pfizer; NY, USA), Ragu describes his current research focuses in measuring and quantitating drugs and metabolites in animal and human samples. Ragu discusses the key challenges associated with studying drug/drug interactions (DDI), the benefits of current technologies available for studying DDI and what to expect from the upcoming Special Focus Issue from Bioanalysis on ‘Novel LC–MS assays impacting CYP and transporter DDI evaluation’.

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Read time: 1:30 mins
Read more about the top advances in bioanalysis for neurological sciences, including a biomarker for autism and a novel method utilizing a combination of probe electrospray ionization (PESI) and tandem mass spectrometry (MS/MS) for imaging metabolites in a live mouse brain.

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Read time: 3:30 mins
The value of lipid biomarkers for precision medicine is growing in recognition, resulting in an increased research focus on translational lipidomic workflows. Underpinning advances in this field are developments in mass spectrometry (MS) and liquid chromatography (LC). In this editorial, David Peake (Thermo Fisher Scientific) considers the analytical challenges associated with translational lipid biomarker development, and how the latest LC–MS technologies and lipidomics workflows are overcoming them.

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