In this editorial, Neil Henderson (AstraZeneca) discusses the explosion in types of drug molecules – the so-called ‘new modality’ drugs – which includes antisense oligonucleotides (ASOs) and modified mRNA.
Discover more about a possible new avenue, free of ion-pairing, for general application in oligonucleotide quantitative LC–MS discovered by researchers in this methodology from Bioanalysis.
In this research article from Bioanalysis the authors discuss the quantitation of larger biotherapeutic proteins such as antibodies and antibody–drug conjugates compared with small molecules by LC–HRMS.
In this interview, Annick De Vries (Sanquin; Amsterdam, Netherlands) discusses how personalized sampling can be utilised to achieve optimal PK/PD data, and how PK measurements translate into real life.
Researchers have developed a novel technology to test for viral infections by detecting small amounts of antibodies in the blood.
A prototype wearable device has been developed to continuously collect live cancer cells directly from a patient’s blood, presenting an alternative to biopsies.
2018 White Paper on Recent Issues in Bioanalysis: ‘A global bioanalytical community perspective on last decade of incurred samples reanalysis (ISR)’ (Part 1 – small molecule regulated bioanalysis, small molecule biomarkers, peptides & oligonucleotide bioanalysis)
This part of the 2018 White Paper published in Bioanalysis discusses the recommendations for LC–MS for small molecules, peptides, oligonucleotides and small molecule biomarkers.
An author’s perspective: George Jaskiw on quantification of phenolic acid metabolites in humans by LC–MS
We talk to George Jaskiw about his work on quantification of phenolic acid metabolites in humans by LC–MS in this interview as part of our author’s perspective series.
We are revisiting this area to explore how the oligonucleotide field has actually developed and provide a critical review of where we are now.
An author’s perspective: Wenying Jian on bioanalytical workflow for novel scaffold protein–drug conjugates
We talk to Wenying Jian about her work on the quantitation of total Centyrin protein using liquid chromatography–tandem mass spectrometry in this interview as part of our author’s perspective series.