We are revisiting this area to explore how the oligonucleotide field has actually developed and provide a critical review of where we are now.
An author’s perspective: Wenying Jian on bioanalytical workflow for novel scaffold protein–drug conjugates
We talk to Wenying Jian about her work on the quantitation of total Centyrin protein using liquid chromatography–tandem mass spectrometry in this interview as part of our author’s perspective series.
Quantification of phenolic acid metabolites in humans by LC–MS: a structural and targeted metabolomics approach
In this research article from Bioanalysis, the authors quantified and identifed over 50 analytes from human biological matrices by HPLC, NMR and LC–MS to obtain structural information on phenolic acid metabolites.
In this Bioanalysis Zone interview, Shane Needham (Alturas Analytics; ID, USA) discusses the advantages and disadvantages of the technologies employed by Alturas Analytics, including microflow LC–MS.
Bioanalytical workflow for novel scaffold protein–drug conjugates: quantitation of total Centyrin protein, conjugated Centyrin and free payload for Centyrin–drug conjugate in plasma and tissue samples using liquid chromatography–tandem mass spectrometry
Alternative scaffold proteins have emerged as novel platforms for development of therapeutic applications. One such application is in protein–drug conjugates, which are analogous to antibody–drug conjugates. Find out more in this research article from Bioanalysis.
Application of Mitra® Microsampling for Pharmacokinetic Bioanalysis of Monoclonal Antibodies in Rats
In this methodology article from Bioanalysis, H Li et al. describe the use of the Mitra® microsampler for blood sampling, ELISA quantitation and PK analysis of two marketed therapeutic monoclonal antibodies administered to rats.
Find out more about working with immunogenicity as well as what the future may hold for the field in this interview with Joyce Slusser (KCAS).
Find out more about a consultants’s perspective on outsourcing in this exclusive interview with Stephanie Pasas-Farmer (BioData Solutions) for Ask the Experts.
Find out what Naidong Weng (Janssen Research and Development) has to say about the future of bioanalytical outsourcing, in this expert interview.
Find out what Marco Michi (Aptuit) has to say about the future of bioanalytical outsourcing, in this expert interview.