In this editorial, Neil Henderson (AstraZeneca) discusses the explosion in types of drug molecules – the so-called ‘new modality’ drugs – which includes antisense oligonucleotides (ASOs) and modified mRNA.
Discover more about a possible new avenue, free of ion-pairing, for general application in oligonucleotide quantitative LC–MS discovered by researchers in this methodology from Bioanalysis.
2018 White Paper on Recent Issues in Bioanalysis: ‘A global bioanalytical community perspective on last decade of incurred samples reanalysis (ISR)’ (Part 1 – small molecule regulated bioanalysis, small molecule biomarkers, peptides & oligonucleotide bioanalysis)
This part of the 2018 White Paper published in Bioanalysis discusses the recommendations for LC–MS for small molecules, peptides, oligonucleotides and small molecule biomarkers.
We are revisiting this area to explore how the oligonucleotide field has actually developed and provide a critical review of where we are now.
Neil Henderson discusses his experiences with oligonucleotides, the technologies that he uses and his work as part of the Translational Biomarker and Bioanalysis group at Astrazeneca.
Challenges and future predictions for oligonucleotide analysis: an interview with Hans-Peter Vornlocher
In this interview Hans-Peter Vornlocher, managing Director of Research at LGC Axolabs (Kulmbach, Germany), reflects on his career in the oligonucleotide field discussing the benefits and challenges of using oligonucleotides, his future predictions and what emerging technologies could aid analysis in the future.
Beyond aptamers: selection of functional oligonucleotide, characterization, chemical synthesis and biotechnological application
In this review article the authors summarize the current development of functional oligonucleotides, called aptamers, focusing on the diagnostic and therapeutic applications.
This infographic presents key results from the oligonucleotide survey.
In this article the authors discuss GMP testing for oligonucleotide drug substance and drug product.
Bioanalysis of Diagnostic and Therapeutic Oligonucleotides: An Emphasis on LC-FL and LC-MS Based Assays
In this article, recent developments and considerations for liquid chromatographic (LC) methods of oligonucleotides are discussed, highlighting LC-Mass Spectrometry and LC-Fluorescence assays, and the benefits of systematic incorporation into a bioanalysis laboratory.